Literature DB >> 7585202

The challenge of fetal gene therapy.

C Coutelle1, A M Douar, W H Colledge, U Froster.   

Abstract

Three recent reports describe the first in vivo attempts at fetal gene therapy. The results underline the need for more intensive studies of the scientific and ethical implications of this new and perhaps more preventive approach to gene therapy.

Mesh：

Year:  1995        PMID： 7585202     DOI： 10.1038/nm0995-864

Source DB:  PubMed          Journal:  Nat Med        ISSN： 1078-8956            Impact factor:   53.440


  7 in total

Review 1.  Prospects for gene therapy in cystic fibrosis.

Authors:  A Jaffé; A Bush; D M Geddes; E W Alton
Journal:  Arch Dis Child       Date:  1999-03       Impact factor: 3.791

2.  Gene transfer to the rodent placenta in situ. A new strategy for delivering gene products to the fetus.

Authors:  M C Senut; S T Suhr; F H Gage
Journal:  J Clin Invest       Date:  1998-04-15       Impact factor: 14.808

3.  Adenoviral vectors can impair adrenocortical steroidogenesis: clinical implications for natural infections and gene therapy.

Authors:  Salvatore Alesci; Walter J Ramsey; Stefan R Bornstein; George P Chrousos; Peter J Hornsby; Salvatore Benvenga; Francesco Trimarchi; Monika Ehrhart-Bornstein
Journal:  Proc Natl Acad Sci U S A       Date:  2002-05-28       Impact factor: 11.205

Review 4.  Drug transfer and metabolism by the human placenta.

Authors:  Michael R Syme; James W Paxton; Jeffrey A Keelan
Journal:  Clin Pharmacokinet       Date:  2004       Impact factor: 6.447

5.  Effective silencing of Sry gene with RNA interference in developing mouse embryos resulted in feminization of XY gonad.

Authors:  Ning Wu; Ai-Bing Yu; Hua-Bin Zhu; Xiu-Kun Lin
Journal:  J Biomed Biotechnol       Date:  2012-02-08

6.  Transplacental RNAi: deciphering gene function in the postimplantation-staged embryo.

Authors:  K Sue O'shea; Lisa S De Boer; Nicole A Slawny; Theresa E Gratsch
Journal:  J Biomed Biotechnol       Date:  2006

7.  Autologous fixed tumor vaccine: a formulation with cytokine-microparticles for protective immunity against recurrence of human hepatocellular carcinoma.

Authors:  Bao Gang Peng; Shu Qin Liu; Ming Kuang; Qiang He; Saeri Totsuka; Lan Huang; Jiefu Huang; Ming-De Lu; Li-Jiang Liang; Kam W Leong; Tadao Ohno
Journal:  Jpn J Cancer Res       Date:  2002-04
  7 in total

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