Literature DB >> 7584950

Immunophilins and the nervous system.

S H Snyder1, D M Sabatini.   

Abstract

The search for immunosuppressant drugs to increase the success of organ transplantation led to the discovery of the immunophilins, proteins that interface with a range of signal transduction systems inside cells, especially in the nervous and immune systems. Here we review how these interesting molecules work and consider their therapeutic potential.

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Year:  1995        PMID： 7584950     DOI： 10.1038/nm0195-32

Source DB:  PubMed          Journal:  Nat Med        ISSN： 1078-8956            Impact factor:   53.440


  32 in total

Review 1.  Constructing molecular complexity and diversity: total synthesis of natural products of biological and medicinal importance.

Authors:  K C Nicolaou; Christopher R H Hale; Christian Nilewski; Heraklidia A Ioannidou
Journal:  Chem Soc Rev       Date:  2012-06-28       Impact factor: 54.564

2.  Ca2+/calcineurin-inhibited adenylyl cyclase, highly abundant in forebrain regions, is important for learning and memory.

Authors:  F A Antoni; M Palkovits; J Simpson; S M Smith; A L Leitch; R Rosie; G Fink; J M Paterson
Journal:  J Neurosci       Date:  1998-12-01       Impact factor: 6.167

3.  Redesigning an FKBP-ligand interface to generate chemical dimerizers with novel specificity.

Authors:  T Clackson; W Yang; L W Rozamus; M Hatada; J F Amara; C T Rollins; L F Stevenson; S R Magari; S A Wood; N L Courage; X Lu; F Cerasoli; M Gilman; D A Holt
Journal:  Proc Natl Acad Sci U S A       Date:  1998-09-01       Impact factor: 11.205

4.  Uncoupling of Ca2+ transport ATPase in muscle and blood platelets by diacylglycerol analogues and cyclosporin A antagonism.

Authors:  C M Cardoso; V M Rumjanek; L De Meis
Journal:  Biochem J       Date:  1997-11-01       Impact factor: 3.857

5.  Postsynaptic calcineurin activity downregulates synaptic transmission by weakening intracellular Ca2+ signaling mechanisms in hippocampal CA1 neurons.

Authors:  J H Wang; P T Kelly
Journal:  J Neurosci       Date:  1997-06-15       Impact factor: 6.167

6.  Neuroprotective actions of FK506 in experimental stroke: in vivo evidence against an antiexcitotoxic mechanism.

Authors:  S P Butcher; D C Henshall; Y Teramura; K Iwasaki; J Sharkey
Journal:  J Neurosci       Date:  1997-09-15       Impact factor: 6.167

7.  The immunophilin FK506-binding protein modulates Ca2+ release channel closure in rat heart.

Authors:  R P Xiao; H H Valdivia; K Bogdanov; C Valdivia; E G Lakatta; H Cheng
Journal:  J Physiol       Date:  1997-04-15       Impact factor: 5.182

8.  Rectification of skeletal muscle ryanodine receptor mediated by FK506 binding protein.

Authors:  J Ma; M B Bhat; J Zhao
Journal:  Biophys J       Date:  1995-12       Impact factor: 4.033

9.  Immunosuppressant FK506 induces interleukin-6 production through the activation of transcription factor nuclear factor (NF)-kappa(B). Implications for FK506 nephropathy.

Authors:  K Muraoka; K Fujimoto; X Sun; K Yoshioka; K Shimizu; M Yagi; H Bose; I Miyazaki; K Yamamoto
Journal:  J Clin Invest       Date:  1996-06-01       Impact factor: 14.808

10.  Dissociation of FKBP12.6 from ryanodine receptor type 2 is regulated by cyclic ADP-ribose but not beta-adrenergic stimulation in mouse cardiomyocytes.

Authors:  Xu Zhang; Yvonne N Tallini; Zheng Chen; Lu Gan; Bin Wei; Robert Doran; Lin Miao; Hong-Bo Xin; Michael I Kotlikoff; Guangju Ji
Journal:  Cardiovasc Res       Date:  2009-07-03       Impact factor: 10.787
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