| Literature DB >> 758468 |
J H Jonkman, L E van Bork, J Wijsbeek, A S Bolhuis-de Vries, R A de Zeeuw, N G Orie, H L Cox.
Abstract
The absorption and metabolism of the quaternary ammonium compound thiazinamium methylsulfate were studied in humans using plasma concentration data and urinary excretion measurements. After giving a dose of 150 mg in suppositories, the relative bioavailability was 5.8 +/- 3.2 (SD) % of the dose, comparable to the values obtained following oral administration. The degree of first-pass effect observed after rectal administration was comparable with that after oral administration.Entities:
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Year: 1979 PMID： 758468 DOI： 10.1002/jps.2600680121
Source DB: PubMed Journal: J Pharm Sci ISSN： 0022-3549 Impact factor: 3.534