| Literature DB >> 7583633 |
A De Mesmaeker1, K H Altmann, A Waldner, S Wendeborn.
Abstract
In the past year major advances have been made in the design, synthesis and characterization of two classes of modified oligonucleotides. In the first class, the phosphodiester backbone of 2'-deoxyribo-oligonucleotides has been replaced in several different ways. The second group represents a completely different type of oligonucleotide modification in which the backbone and the 2'-deoxyribose moieties are replaced by amino acids. These advances present new possibilities for the pharmaceutical applications of modified oligonucleotides in antisense strategies.Entities:
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Year: 1995 PMID： 7583633 DOI： 10.1016/0959-440x(95)80096-4
Source DB: PubMed Journal: Curr Opin Struct Biol ISSN： 0959-440X Impact factor: 6.809