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Literature DB >> 7583627

RNA cleavage by small catalytic RNAs.

Abstract

Recent studies of the hammerhead ribozyme have provided an insight into its three-dimensional structure. In addition, studies using chemical probes, functional-group modification and mutational analysis, in combination with computer modelling, have led to proposals for the structure of both the hairpin and hepatitis delta virus ribozymes. Such structural elucidations will aid understanding of the mechanism of ribozyme catalysis. The discovery that certain RNA-binding proteins can increase the catalytic efficiency of ribozymes in encouraging for their use in the inhibition of gene expression in vivo.

Entities: Species

Mesh：

Substances：
RNA, Catalytic
RNA

Year: 1995 PMID： 7583627 DOI： 10.1016/0959-440x(95)80090-5

Source DB: PubMed Journal: Curr Opin Struct Biol ISSN： 0959-440X Impact factor: 6.809

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Cited

7 in total

1. Comparison of the specificities and catalytic activities of hammerhead ribozymes and DNA enzymes with respect to the cleavage of BCR-ABL chimeric L6 (b2a2) mRNA.

Authors: T Kuwabara; M Warashina; T Tanabe; K Tani; S Asano; K Taira
Journal: Nucleic Acids Res Date: 1997-08-01 Impact factor: 16.971

2. Sequence specificity of the hammerhead ribozyme revisited; the NHH rule.

Authors: A R Kore; N K Vaish; U Kutzke; F Eckstein
Journal: Nucleic Acids Res Date: 1998-09-15 Impact factor: 16.971

Review 3. Hammerhead ribozyme kinetics.

Authors: T K Stage-Zimmermann; O C Uhlenbeck
Journal: RNA Date: 1998-08 Impact factor: 4.942

7. Base and sugar requirements for RNA cleavage of essential nucleoside residues in internal loop B of the hairpin ribozyme: implications for secondary structure.

Authors: S Schmidt; L Beigelman; A Karpeisky; N Usman; U S Sorensen; M J Gait
Journal: Nucleic Acids Res Date: 1996-02-15 Impact factor: 16.971

7 in total

RNA cleavage by small catalytic RNAs.

1. Comparison of the specificities and catalytic activities of hammerhead ribozymes and DNA enzymes with respect to the cleavage of BCR-ABL chimeric L6 (b2a2) mRNA.

2. Sequence specificity of the hammerhead ribozyme revisited; the NHH rule.

Review 3. Hammerhead ribozyme kinetics.

Review 4. Antiviral ribozymes. New jobs for ancient molecules.

Review 5. Plant pathogenic RNAs and RNA catalysis.

6. In vitro selection of hammerhead ribozymes containing a bulged nucleotide in stem II.

7. Base and sugar requirements for RNA cleavage of essential nucleoside residues in internal loop B of the hairpin ribozyme: implications for secondary structure.