Literature DB >> 7583247

Eicosanoids are produced by microglia, not by astrocytes, in rat glial cell cultures.

M Matsuo1, Y Hamasaki, F Fujiyama, S Miyazaki.   

Abstract

To determine principal sources of eicosanoid production in glial cells, we analyzed the metabolites of arachidonic acid in cultured rat glial cells by use of reversed-phase, high-performance liquid chromatography and an on-line radioisotope detector. Prostaglandin D2, leukotriene B4, leukotriene C4, and 5-hydroxyeicosatetraenoic acid were present in cultures in which microglia appeared on a monolayer astrocytes. None were detected in culture dishes that contained only astrocytes, although astrocytes have been believed to be a main source of eicosanoid production in brain.

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Year:  1995        PMID： 7583247     DOI： 10.1016/0006-8993(95)00490-h

Source DB:  PubMed          Journal:  Brain Res        ISSN： 0006-8993            Impact factor:   3.252


  15 in total

1.  Lipoxin A4 inhibits 5-lipoxygenase translocation and leukotrienes biosynthesis to exert a neuroprotective effect in cerebral ischemia/reperfusion injury.

Authors:  Le Wu; Sen Miao; Lin-Bing Zou; Ping Wu; Hua Hao; Ke Tang; Pan Zeng; Jing Xiong; Hong-Hua Li; Qiang Wu; Lei Cai; Du-Yun Ye
Journal:  J Mol Neurosci       Date:  2012-06-03       Impact factor: 3.444

2.  Regional difference in susceptibility to lipopolysaccharide-induced neurotoxicity in the rat brain: role of microglia.

Authors:  W G Kim; R P Mohney; B Wilson; G H Jeohn; B Liu; J S Hong
Journal:  J Neurosci       Date:  2000-08-15       Impact factor: 6.167

3.  Pharmacokinetics and efficacy of PT302, a sustained-release Exenatide formulation, in a murine model of mild traumatic brain injury.

Authors:  Miaad Bader; Yazhou Li; Daniela Lecca; Vardit Rubovitch; David Tweedie; Elliot Glotfelty; Lital Rachmany; Hee Kyung Kim; Ho-Il Choi; Barry J Hoffer; Chaim G Pick; Nigel H Greig; Dong Seok Kim
Journal:  Neurobiol Dis       Date:  2018-11-22       Impact factor: 5.996

4.  Production of leukotrienes in a model of focal cerebral ischaemia in the rat.

Authors:  P Ciceri; M Rabuffetti; A Monopoli; S Nicosia
Journal:  Br J Pharmacol       Date:  2001-08       Impact factor: 8.739

5.  Upregulation of RANTES gene expression in neuroglia by Japanese encephalitis virus infection.

Authors:  Chun-Jung Chen; Jian-Hong Chen; Shih-Yun Chen; Su-Lan Liao; Shue-Ling Raung
Journal:  J Virol       Date:  2004-11       Impact factor: 5.103

Review 6.  Cyclooxygenases and 5-lipoxygenase in Alzheimer's disease.

Authors:  Hari Manev; Hu Chen; Svetlana Dzitoyeva; Radmila Manev
Journal:  Prog Neuropsychopharmacol Biol Psychiatry       Date:  2010-08-05       Impact factor: 5.067

7.  Toxoplasma gondii infection of neurons induces neuronal cytokine and chemokine production, but gamma interferon- and tumor necrosis factor-stimulated neurons fail to inhibit the invasion and growth of T. gondii.

Authors:  D Schlüter; M Deckert; H Hof; K Frei
Journal:  Infect Immun       Date:  2001-12       Impact factor: 3.441

8.  Intracerebroventricular injection of leukotriene B4 attenuates antigen-induced asthmatic response via BLT1 receptor stimulating HPA-axis in sensitized rats.

Authors:  Shui-Juan Zhang; Yang-Mei Deng; Yi-Liang Zhu; Xin-Wei Dong; Jun-Xia Jiang; Qiang-Min Xie
Journal:  Respir Res       Date:  2010-04-20

9.  Leukotriene B4, administered via intracerebroventricular injection, attenuates the antigen-induced asthmatic response in sensitized guinea pigs.

Authors:  Yi-Liang Zhu; Shui-Jun Zhang; Yang-Mei Deng; Xin-Wei Dong; Jun-Xia Jiang; Qiang-Min Xie
Journal:  J Neuroinflammation       Date:  2010-02-11       Impact factor: 8.322

10.  Lipopolysaccharide injected into the cerebral ventricle evokes fever through induction of cyclooxygenase-2 in brain endothelial cells.

Authors:  C Cao; K Matsumura; M Ozaki; Y Watanabe
Journal:  J Neurosci       Date:  1999-01-15       Impact factor: 6.167
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