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Literature DB >> 7583121

Transcriptional control by protein phosphorylation: signal transmission from the cell surface to the nucleus.

Abstract

Two general mechanisms have evolved for the rapid and accurate transmission of signals from cell-surface receptors to the nucleus, both involving protein phosphorylation. One mechanism depends on the regulated translocation of activated protein kinases from the cytoplasm to the nucleus, where they phosphorylate target transcription factors. In the second mechanism, transcription factors are kept in a latent state in the cytoplasm and are translocated into the nucleus upon activation.

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Year: 1995 PMID： 7583121 DOI： 10.1016/s0960-9822(95)00151-5

Source DB: PubMed Journal: Curr Biol ISSN： 0960-9822 Impact factor: 10.834

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Cited

161 in total

1. A nuclear tyrosine phosphorylation circuit: c-Jun as an activator and substrate of c-Abl and JNK.

Authors: D Barilá; R Mangano; S Gonfloni; J Kretzschmar; M Moro; D Bohmann; G Superti-Furga
Journal: EMBO J Date: 2000-01-17 Impact factor: 11.598

2. SIMKK, a mitogen-activated protein kinase (MAPK) kinase, is a specific activator of the salt stress-induced MAPK, SIMK.

Authors: S Kiegerl; F Cardinale; C Siligan; A Gross; E Baudouin; A Liwosz; S Eklöf; S Till; L Bögre; H Hirt; I Meskiene
Journal: Plant Cell Date: 2000-11 Impact factor: 11.277

3. Formation of C/EBP transcription factors and possible pathways for controlling their activity during learning in Helix.

Authors: L N Grinkevich
Journal: Neurosci Behav Physiol Date: 2002 Jan-Feb

4. Formation of AP-1 transcription factors during learning in Helix.

Authors: L N Grinkevich; P D Lisachev; T I Merkulova
Journal: Neurosci Behav Physiol Date: 2003-01

5. Cytoplasmic catalytic subunit of protein kinase A mediates cross-repression by NF-kappa B and the glucocorticoid receptor.

Authors: V Doucas; Y Shi; S Miyamoto; A West; I Verma; R M Evans
Journal: Proc Natl Acad Sci U S A Date: 2000-10-24 Impact factor: 11.205

6. The SMRT corepressor is regulated by a MEK-1 kinase pathway: inhibition of corepressor function is associated with SMRT phosphorylation and nuclear export.

Authors: S H Hong; M L Privalsky
Journal: Mol Cell Biol Date: 2000-09 Impact factor: 4.272

Transcriptional control by protein phosphorylation: signal transmission from the cell surface to the nucleus.

1. A nuclear tyrosine phosphorylation circuit: c-Jun as an activator and substrate of c-Abl and JNK.

2. SIMKK, a mitogen-activated protein kinase (MAPK) kinase, is a specific activator of the salt stress-induced MAPK, SIMK.

3. Formation of C/EBP transcription factors and possible pathways for controlling their activity during learning in Helix.

4. Formation of AP-1 transcription factors during learning in Helix.

5. Cytoplasmic catalytic subunit of protein kinase A mediates cross-repression by NF-kappa B and the glucocorticoid receptor.

6. The SMRT corepressor is regulated by a MEK-1 kinase pathway: inhibition of corepressor function is associated with SMRT phosphorylation and nuclear export.

7. UV-induced hyperphosphorylation of replication protein a depends on DNA replication and expression of ATM protein.

Review 8. Regulation of phospholipid synthesis in the yeast Saccharomyces cerevisiae.

9. Activation of the STAT signaling pathway can cause expression of caspase 1 and apoptosis.

Review 10. Selectivity and potency of cyclin-dependent kinase inhibitors.