| Literature DB >> 7579330 |
A A Khamlichi1, A Rocca, G Touchard, P Aucouturier, J L Preud'homme, M Cogné.
Abstract
Light chain deposition disease (LCDD) results from a propensity of some human monoclonal L chains to form tissue deposits. We designed an experimental model for in vivo expression of human kappa L chain sequences in mice and compared a somatically mutated LCDD chain with a closely related control kappa chain, both encoded by the unique V kappa IV gene. Mice secreting the LCDD chain but not those producing the control chain showed deposits with a distribution similar to that observed in patients. These data show that discrete changes in V region sequences can play a major role in tissue deposition of human L chains.Entities:
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Year: 1995 PMID： 7579330
Source DB: PubMed Journal: Blood ISSN： 0006-4971 Impact factor: 22.113