Literature DB >> 7579129

Superoxide-dependent depletion of reduced glutathione by L-DOPA and dopamine. Relevance to Parkinson's disease.

J P Spencer1, P Jenner, B Halliwell.   

Abstract

The mechanism of nigral cell death in Parkinson's disease (PD) remains unknown, but it is increasingly proposed that free radical reactions are important in the disease pathology. One of the most striking features of PD is an approximate 40% decrease in the levels of reduced glutathione (GSH) which occurs early in the development of the disease. We describe a possible mechanism of GSH depletion which results from the reaction of L-DOPA and dopamine with the superoxide free radical (O2.-) and leads to a very rapid loss of GSH.

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Year:  1995        PMID： 7579129     DOI： 10.1097/00001756-199507310-00004

Source DB:  PubMed          Journal:  Neuroreport        ISSN： 0959-4965            Impact factor:   1.837


  21 in total

1.  Glutathione conjugates with dopamine-derived quinones to form reactive or non-reactive glutathione-conjugates.

Authors:  Zhi Dong Zhou; Tit Meng Lim
Journal:  Neurochem Res       Date:  2010-08-19       Impact factor: 3.996

2.  Neuroinflammation, Oxidative Stress and the Pathogenesis of Parkinson's Disease.

Authors:  R Lee Mosley; Eric J Benner; Irena Kadiu; Mark Thomas; Michael D Boska; Khader Hasan; Chad Laurie; Howard E Gendelman
Journal:  Clin Neurosci Res       Date:  2006-12-06

3.  The Therapeutic Implications of Tea Polyphenols Against Dopamine (DA) Neuron Degeneration in Parkinson's Disease (PD).

Authors:  Zhi Dong Zhou; Shao Ping Xie; Wuan Ting Saw; Patrick Ghim Hoe Ho; Hongyan Wang; Zhou Lei; Zhao Yi; Eng King Tan
Journal:  Cells       Date:  2019-08-16       Impact factor: 6.600

4.  Disubstituted Dithiolethione ACDT Exerts Neuroprotective Effects Against 6-Hydroxydopamine-Induced Oxidative Stress in SH-SY5Y Cells.

Authors:  Swati Betharia; Alejandro N Rondόn-Ortiz; Dennis A Brown
Journal:  Neurochem Res       Date:  2019-06-04       Impact factor: 3.996

5.  Manganese increases L-DOPA auto-oxidation in the striatum of the freely moving rat: potential implications to L-DOPA long-term therapy of Parkinson's disease.

Authors:  P A Serra; G Esposito; P Enrico; M A Mura; R Migheli; M R Delogu; M Miele; M S Desole; G Grella; E Miele
Journal:  Br J Pharmacol       Date:  2000-06       Impact factor: 8.739

6.  Intracellular metabolism and bioactivity of quercetin and its in vivo metabolites.

Authors:  Jeremy P E Spencer; Gunter G C Kuhnle; Robert J Williams; Catherine Rice-Evans
Journal:  Biochem J       Date:  2003-05-15       Impact factor: 3.857

7.  Substrate specificity of human glutamine transaminase K as an aminotransferase and as a cysteine S-conjugate beta-lyase.

Authors:  Arthur J L Cooper; John T Pinto; Boris F Krasnikov; Zoya V Niatsetskaya; Qian Han; Jianyong Li; David Vauzour; Jeremy P E Spencer
Journal:  Arch Biochem Biophys       Date:  2008-02-29       Impact factor: 4.013

8.  Potent induction of total cellular GSH and NQO1 as well as mitochondrial GSH by 3H-1,2-dithiole-3-thione in SH-SY5Y neuroblastoma cells and primary human neurons: protection against neurocytotoxicity elicited by dopamine, 6-hydroxydopamine, 4-hydroxy-2-nonenal, or hydrogen peroxide.

Authors:  Zhenquan Jia; Hong Zhu; Hara P Misra; Yunbo Li
Journal:  Brain Res       Date:  2008-01-03       Impact factor: 3.252

9.  Roles of glutathione (GSH) in dopamine (DA) oxidation studied by improved tandem HPLC plus ESI-MS.

Authors:  Zhi Dong Zhou; Tit Meng Lim
Journal:  Neurochem Res       Date:  2008-07-05       Impact factor: 3.996

10.  The neuroprotective potential of flavonoids: a multiplicity of effects.

Authors:  David Vauzour; Katerina Vafeiadou; Ana Rodriguez-Mateos; Catarina Rendeiro; Jeremy P E Spencer
Journal:  Genes Nutr       Date:  2008-12       Impact factor: 5.523
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