Literature DB >> 7579030

The effect of caffeine on the pharmacokinetics of acetaminophen in man.

N Iqbal1, B Ahmad, K H Janbaz, A U Gilani, S K Niazi.   

Abstract

The influence of caffeine (60 mg) was studied on the pharmacokinetic characteristics of acetaminophen (500 mg single dose) in ten healthy male human volunteers in a complete cross-over design. A high-performance liquid chromatography (HPLC) method was used to analyse serum drug concentrations. Caffeine caused a highly significant (p < 0.01) increase in AUC and AUMC, a significant (p < 0.05) increase in Cmax, and a significant (p < 0.05) decrease in clearance (C1/F) of acetaminophen. We conclude that caffeine taken in doses commonly available commercially or in a cup of coffee can significantly potentiate the therapeutic potential of acetaminophen in man.

Entities:  

Mesh：

Substances：

Year:  1995        PMID： 7579030     DOI： 10.1002/bdd.2510160606

Source DB:  PubMed          Journal:  Biopharm Drug Dispos        ISSN： 0142-2782            Impact factor:   1.627


  7 in total

Review 1.  Combined analgesics in (headache) pain therapy: shotgun approach or precise multi-target therapeutics?

Authors:  Andreas Straube; Bernhard Aicher; Bernd L Fiebich; Gunther Haag
Journal:  BMC Neurol       Date:  2011-03-31       Impact factor: 2.474

Review 2.  Clinically significant pharmacokinetic interactions between dietary caffeine and medications.

Authors:  J A Carrillo; J Benitez
Journal:  Clin Pharmacokinet       Date:  2000-08       Impact factor: 6.447

3.  Tolerability and efficacy of a combination of paracetamol and caffeine in the treatment of tension-type headache: a randomised, double-blind, double-dummy, cross-over study versus placebo and naproxen sodium.

Authors:  Luigi Alberto Pini; Enrico Del Bene; Giorgio Zanchin; Paola Sarchielli; Girolamo Di Trapani; Maria Pia Prudenzano; Giovanni LaPegna; Lidia Savi; Giorgio Di Loreto; Paolo Dionisio; Franco Granella
Journal:  J Headache Pain       Date:  2008-09-25       Impact factor: 7.277

Review 4.  Caffeine and headaches.

Authors:  Robert E Shapiro
Journal:  Curr Pain Headache Rep       Date:  2008-08

5.  Multiscale modeling reveals inhibitory and stimulatory effects of caffeine on acetaminophen-induced toxicity in humans.

Authors:  C Thiel; H Cordes; V Baier; L M Blank; L Kuepfer
Journal:  CPT Pharmacometrics Syst Pharmacol       Date:  2017-01-28

6.  Effect of Caffeine on the Bioavailability and Pharmacokinetics of an Acetylsalicylic Acid-Paracetamol Combination: Results of a Phase I Study.

Authors:  Thomas Weiser; Harald Weigmann
Journal:  Adv Ther       Date:  2019-02-13       Impact factor: 3.845

7.  Caffeine modulates pharmacokinetic and pharmacodynamic profiles of pioglitazone in diabetic rats: Impact on therapeutics.

Authors:  Ali M Alshabi; Saad A Alkahtani; Ibrahim A Shaikh; Mohammed S Habeeb
Journal:  Saudi Med J       Date:  2021-02       Impact factor: 1.484
  7 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.