Literature DB >> 7576234

Induction of apoptosis in thymocytes: new evidence for an interaction of PKC and PKA pathways.

F Ojeda1, H Folch, M I Guarda, B Jastorff, H A Diehl.   

Abstract

The second messenger cascades connected to PKC and PKA are involved in the induction of apoptosis. Here we study the interaction of those two second messenger pathways with respect to the induction of apoptosis by stimulation or inhibition. The stimulators used were phorbol dibutyrate for PKC and one of the cAMP agonists Sp-5,6 DCl-cBIMPS or Sp-cAMP for PKA. The inhibitors used were staurosporin for PKC and the cAMP antagonist Rp-cAMPS for PKA. We found a synergism between both second messenger systems with regard to the induction of apoptosis in thymus lymphocytes.

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Year:  1995        PMID： 7576234

Source DB:  PubMed          Journal:  Biol Chem Hoppe Seyler        ISSN： 0177-3593


  4 in total

Review 1.  [Significance of apoptotic processes in radiotherapy. I].

Authors:  M Abend; D van Beuningen
Journal:  Strahlenther Onkol       Date:  1998-03       Impact factor: 3.621

Review 2.  Role of protein kinase activity in apoptosis.

Authors:  M F Lavin; D Watters; Q Song
Journal:  Experientia       Date:  1996-10-31

3.  Extracellular human immunodeficiency virus type 1 Tat protein is associated with an increase in both NF-kappa B binding and protein kinase C activity in primary human astrocytes.

Authors:  K Conant; M Ma; A Nath; E O Major
Journal:  J Virol       Date:  1996-03       Impact factor: 5.103

4.  Cytolysis by CCR5-using human immunodeficiency virus type 1 envelope glycoproteins is dependent on membrane fusion and can be inhibited by high levels of CD4 expression.

Authors:  Jason A LaBonte; Navid Madani; Joseph Sodroski
Journal:  J Virol       Date:  2003-06       Impact factor: 5.103
  4 in total

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