Literature DB >> 7575986

Prodrugs of anthracycline antibiotics suited for tumor-specific activation.

M Azoulay1, J C Florent, C Monneret, J P Gesson, J C Jacquesy, F Tillequin, M Koch, K Bosslet, J Czech, D Hoffman.   

Abstract

The two novel prodrugs 4 and 11 have been prepared from tetra-O-acetyl-D-galactopyranose and doxorubicin in three and six steps, respectively. Their low cytotoxicity, high stability in plasma and, in the case of 11, efficient hydrolysis in the presence of alpha-galactosidase, fulfill preliminary conditions for their use in combination with monoclonal antibody-enzyme conjugates.

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Year:  1995        PMID： 7575986

Source DB:  PubMed          Journal:  Anticancer Drug Des        ISSN： 0266-9536


  3 in total

Review 1.  The role of beta-glucuronidase in drug disposition and drug targeting in humans.

Authors:  B Sperker; J T Backman; H K Kroemer
Journal:  Clin Pharmacokinet       Date:  1997-07       Impact factor: 6.447

2.  Synthesis of the next-generation therapeutic antibodies that combine cell targeting and antibody-catalyzed prodrug activation.

Authors:  Sunny Abraham; Fang Guo; Lian-Sheng Li; Christoph Rader; Cheng Liu; Carlos F Barbas; Richard A Lerner; Subhash C Sinha
Journal:  Proc Natl Acad Sci U S A       Date:  2007-03-19       Impact factor: 11.205

3.  Synthesis, identification and in vivo studies of tumor-targeting agent peptide doxorubicin (PDOX) to treat peritoneal carcinomatosis of gastric cancer with similar efficacy but reduced toxicity.

Authors:  Li Tang; Rui Duan; Yan-jun Zhong; Raymond A Firestone; Ya-ping Hong; Ji-guo Li; Yan-chao Xin; Han-lin Wu; Yan Li
Journal:  Mol Cancer       Date:  2014-03-03       Impact factor: 27.401
  3 in total

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