OBJECTIVE: To assess the use of quantitative bone scanning (QBS) in the monitoring of patients with intravenous pamidronate-treated symptomatic monostotic Paget's disease of bone in whom biochemical markers of bone turnover are relatively normal. METHODS: QBS was performed in 9 patients and the results were expressed as a ratio, obtained by comparing isotope uptake at an affected and a control (unaffected) site. RESULTS: Serum alkaline phosphatase levels were normal in 7 of the 9 patients and changed minimally with treatment. The median QBS ratio was 2.72 (range 1.69-24.6) at baseline and 1.49 (range 0.63-4.18) posttreatment (P = 0.008). The median symptom score decreased with treatment, but QBS ratios provided the only objective measure of disease activity by which response to pamidronate therapy could be judged. CONCLUSION: QBS may be a useful technique for evaluating the effects of treatment in patients with Paget's disease of bone.
OBJECTIVE: To assess the use of quantitative bone scanning (QBS) in the monitoring of patients with intravenous pamidronate-treated symptomatic monostotic Paget's disease of bone in whom biochemical markers of bone turnover are relatively normal. METHODS: QBS was performed in 9 patients and the results were expressed as a ratio, obtained by comparing isotope uptake at an affected and a control (unaffected) site. RESULTS: Serum alkaline phosphatase levels were normal in 7 of the 9 patients and changed minimally with treatment. The median QBS ratio was 2.72 (range 1.69-24.6) at baseline and 1.49 (range 0.63-4.18) posttreatment (P = 0.008). The median symptom score decreased with treatment, but QBS ratios provided the only objective measure of disease activity by which response to pamidronate therapy could be judged. CONCLUSION: QBS may be a useful technique for evaluating the effects of treatment in patients with Paget's disease of bone.
Authors: Martin Libicher; C Kasperk; M Daniels-Wredenhagen; T Heye; H U Kauczor; P Nawroth; S Delorme; W Hosch Journal: Skeletal Radiol Date: 2012-05-16 Impact factor: 2.199
Authors: Owen Cronin; Laura Forsyth; Kirsteen Goodman; Steff C Lewis; Catriona Keerie; Allan Walker; Mary Porteous; Roseanne Cetnarskyj; Lakshminarayan R Ranganath; Peter L Selby; Geeta Hampson; Rama Chandra; Shu Ho; Jon H Tobias; Steven Young-Min; Malachi J McKenna; Rachel K Crowley; William D Fraser; Luigi Gennari; Ranuccio Nuti; Maria Luisa Brandi; Javier Del Pino-Montes; Jean-Pierre Devogelaer; Anne Durnez; Giancarlo Isaia; Marco Di Stefano; Núria Guañabens; Josep Blanch; Markus J Seibel; John P Walsh; Mark A Kotowicz; Geoffrey C Nicholson; Emma L Duncan; Gabor Major; Anne Horne; Nigel L Gilchrist; Maarten Boers; Gordon D Murray; Keith Charnock; Diana Wilkinson; R Graham G Russell; Stuart H Ralston Journal: BMJ Open Date: 2019-09-04 Impact factor: 2.692