Literature DB >> 7575476

Physiological control of metabolic flux: the requirement for multisite modulation.

D A Fell1, S Thomas.   

Abstract

Biochemists have long assumed that the flux through a metabolic pathway can be controlled by the activity of a key regulatory enzyme near the beginning of the pathway. We present the accumulating evidence that every step in this assumption is flawed. Instead, effective physiological control of metabolism is shown to involve simultaneous multisite modulation through action on a number of enzymes.

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Year:  1995        PMID： 7575476      PMCID： PMC1136115          DOI： 10.1042/bj3110035

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.857


  36 in total

1.  Equilibria of two-partner reactions of energy supplying metabolism in muscle.

Authors:  H J HOHORST; M REIM; H BARTELS
Journal:  Biochem Biophys Res Commun       Date:  1962-04-03       Impact factor: 3.575

Review 2.  Genetics and intermediary metabolism.

Authors:  D G Fraenkel
Journal:  Annu Rev Genet       Date:  1992       Impact factor: 16.830

3.  Control theory of regulatory cascades.

Authors:  D Kahn; H V Westerhoff
Journal:  J Theor Biol       Date:  1991-11-21       Impact factor: 2.691

4.  A linear steady-state treatment of enzymatic chains. General properties, control and effector strength.

Authors:  R Heinrich; T A Rapoport
Journal:  Eur J Biochem       Date:  1974-02-15

Review 5.  17th Fritz Lipmann Lecture. Wanderings (wonderings) in metabolism.

Authors:  P A Srere
Journal:  Biol Chem Hoppe Seyler       Date:  1993-09

Review 6.  Transcriptional control of genes that regulate glycolysis and gluconeogenesis in adult liver.

Authors:  F P Lemaigre; G G Rousseau
Journal:  Biochem J       Date:  1994-10-01       Impact factor: 3.857

7.  Isolation and characterization of the two structural genes coding for phosphofructokinase in yeast.

Authors:  J Heinisch
Journal:  Mol Gen Genet       Date:  1986-01

8.  Effects of overexpression of phosphofructokinase on glycolysis in the yeast Saccharomyces cerevisiae.

Authors:  S E Davies; K M Brindle
Journal:  Biochemistry       Date:  1992-05-19       Impact factor: 3.162

9.  Positional cloning of the mouse obese gene and its human homologue.

Authors:  Y Zhang; R Proenca; M Maffei; M Barone; L Leopold; J M Friedman
Journal:  Nature       Date:  1994-12-01       Impact factor: 49.962

10.  Overproduction of glycolytic enzymes in yeast.

Authors:  I Schaaff; J Heinisch; F K Zimmermann
Journal:  Yeast       Date:  1989 Jul-Aug       Impact factor: 3.239
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  51 in total

1.  Interrelations of ATP synthesis and proton handling in ischaemically exercising human forearm muscle studied by 31P magnetic resonance spectroscopy.

Authors:  G J Kemp; M Roussel; D Bendahan; Y Le Fur; P J Cozzone
Journal:  J Physiol       Date:  2001-09-15       Impact factor: 5.182

2.  Control of the threonine-synthesis pathway in Escherichia coli: a theoretical and experimental approach.

Authors:  C Chassagnole; D A Fell; B Raïs; B Kudla; J P Mazat
Journal:  Biochem J       Date:  2001-06-01       Impact factor: 3.857

3.  Glyceraldehyde-3-phosphate dehydrogenase has no control over glycolytic flux in Lactococcus lactis MG1363.

Authors:  Christian Solem; Brian J Koebmann; Peter R Jensen
Journal:  J Bacteriol       Date:  2003-03       Impact factor: 3.490

4.  Elasticity analysis and design for large metabolic responses produced by changes in enzyme activities.

Authors:  Fernando Ortega; Luis Acerenza
Journal:  Biochem J       Date:  2002-10-01       Impact factor: 3.857

5.  Protein phosphorylation can regulate metabolite concentrations rather than control flux: the example of glycogen synthase.

Authors:  James R A Schafer; David A Fell; Douglas Rothman; Robert G Shulman
Journal:  Proc Natl Acad Sci U S A       Date:  2004-01-26       Impact factor: 11.205

6.  Expression of genes encoding F(1)-ATPase results in uncoupling of glycolysis from biomass production in Lactococcus lactis.

Authors:  Brian J Koebmann; Christian Solem; Martin B Pedersen; Dan Nilsson; Peter R Jensen
Journal:  Appl Environ Microbiol       Date:  2002-09       Impact factor: 4.792

7.  Network analysis of enzyme activities and metabolite levels and their relationship to biomass in a large panel of Arabidopsis accessions.

Authors:  Ronan Sulpice; Sandra Trenkamp; Matthias Steinfath; Bjorn Usadel; Yves Gibon; Hanna Witucka-Wall; Eva-Theresa Pyl; Hendrik Tschoep; Marie Caroline Steinhauser; Manuela Guenther; Melanie Hoehne; Johann M Rohwer; Thomas Altmann; Alisdair R Fernie; Mark Stitt
Journal:  Plant Cell       Date:  2010-08-10       Impact factor: 11.277

8.  Is the regulation of galactose 1-phosphate tuned against gene expression noise?

Authors:  Pedro de Atauri; David Orrell; Stephen Ramsey; Hamid Bolouri
Journal:  Biochem J       Date:  2005-04-01       Impact factor: 3.857

9.  Control of muscle glucose uptake: test of the rate-limiting step paradigm in conscious, unrestrained mice.

Authors:  Patrick T Fueger; Jane Shearer; Deanna P Bracy; Kelly A Posey; R Richard Pencek; Owen P McGuinness; David H Wasserman
Journal:  J Physiol       Date:  2004-12-02       Impact factor: 5.182

Review 10.  Sirtuins-Mediated System-Level Regulation of Mammalian Tissues at the Interface between Metabolism and Cell Cycle: A Systematic Review.

Authors:  Parcival Maissan; Eva J Mooij; Matteo Barberis
Journal:  Biology (Basel)       Date:  2021-03-04
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