OBJECTIVES: The major objective of this study was to test vitamin E as a potential radioprotectant for the small bowel of the rat. SUMMARY BACKGROUND DATA: Vitamin E has previously been shown to provide radioprotection in animal models: increased survival after whole-body irradiation, diminished absorptive malfunction, and modest diminution in postirradiation hemolysis. The lumenal route for intestinal radioprotection has not been tested. METHODS: Rat mid-small bowel was surgically exteriorized and segmented by ties into compartments, each of which was filled with a test solution 30 minutes before 1100 cGy of x-irradiation was administered. After the rats were killed 5 days later, the various segments were evaluated for surviving crypts, mucosal height, and goblet cell preservation. Lumenal agents included alpha-tocopherol phosphate and alpha-tocopherol acetate. In a separate study, dietary supplements of alpha-tocopherol were given for 10 days before irradiation, and the same irradiation sequence was carried out. RESULTS: Small bowel crypt cell numbers, mucosal height, and goblet cell numbers were significantly protected from radiation effects by dietary alpha tocopherol pretreatment and by lumenal application of the vitamin. CONCLUSIONS: These studies indicate that vitamin E can serve as a partial protectant against acute irradiation enteritis, whether given as chronic oral systemic pretreatment or as a brief topical application.
OBJECTIVES: The major objective of this study was to test vitamin E as a potential radioprotectant for the small bowel of the rat. SUMMARY BACKGROUND DATA: Vitamin E has previously been shown to provide radioprotection in animal models: increased survival after whole-body irradiation, diminished absorptive malfunction, and modest diminution in postirradiation hemolysis. The lumenal route for intestinal radioprotection has not been tested. METHODS:Rat mid-small bowel was surgically exteriorized and segmented by ties into compartments, each of which was filled with a test solution 30 minutes before 1100 cGy of x-irradiation was administered. After the rats were killed 5 days later, the various segments were evaluated for surviving crypts, mucosal height, and goblet cell preservation. Lumenal agents included alpha-tocopherol phosphate and alpha-tocopherol acetate. In a separate study, dietary supplements of alpha-tocopherol were given for 10 days before irradiation, and the same irradiation sequence was carried out. RESULTS: Small bowel crypt cell numbers, mucosal height, and goblet cell numbers were significantly protected from radiation effects by dietary alpha tocopherol pretreatment and by lumenal application of the vitamin. CONCLUSIONS: These studies indicate that vitamin E can serve as a partial protectant against acute irradiation enteritis, whether given as chronic oral systemic pretreatment or as a brief topical application.
Authors: O Giardini; M Taccone-Gallucci; R Lubrano; G Ricciardi-Tenore; D Bandino; I Silvi; C Paradisi; O Mannarino; G Citti; M Elli Journal: Clin Nephrol Date: 1984-03 Impact factor: 0.975
Authors: M M Kligerman; D J Glover; A T Turrisi; A L Norfleet; J M Yuhas; L R Coia; C Simone; J H Glick; R L Goodman Journal: Int J Radiat Oncol Biol Phys Date: 1984-09 Impact factor: 7.038
Authors: Marjolaine Roche; Francis W Kemp; Amit Agrawal; Alicia Attanasio; Prasad V S V Neti; Roger W Howell; Ronaldo P Ferraris Journal: Free Radic Biol Med Date: 2010-10-21 Impact factor: 7.376
Authors: Maaike Berbée; Qiang Fu; Marjan Boerma; K Sree Kumar; David S Loose; Martin Hauer-Jensen Journal: Genes Nutr Date: 2011-04-24 Impact factor: 5.523
Authors: Marjolaine Roche; Prasad V S V Neti; Francis W Kemp; Edouard I Azzam; Ronaldo P Ferraris; Roger W Howell Journal: Radiat Res Date: 2015-10-20 Impact factor: 2.841
Authors: Letícia de Freitas Cuba; Aroldo Braga Filho; Karen Cherubini; Fernanda Gonçalves Salum; Maria Antonia Zancanaro de Figueiredo Journal: Support Care Cancer Date: 2015-12-23 Impact factor: 3.603
Authors: Vijayalakshmi Sridharan; Sunil K Sharma; Eduardo G Moros; Peter M Corry; Preeti Tripathi; Benjamin J Lieblong; Chandan Guha; Martin Hauer-Jensen; Marjan Boerma Journal: Int J Radiat Biol Date: 2013-04-16 Impact factor: 2.694