Literature DB >> 7574052

Postoperative analgesia using epidural infusions of fentanyl with bupivacaine. A prospective analysis of 1,014 patients.

D A Scott1, D S Beilby, C McClymont.   

Abstract

BACKGROUND: Epidural fentanyl/bupivacaine infusions often are limited to high dependency units or intensive care units. One thousand fourteen patients receiving epidural fentanyl/bupivacaine infusions for analgesia after major surgery who were managed in the general surgical ward were prospectively surveyed.
METHODS: Patients leaving the recovery room with an epidural catheter in situ were assessed three times a day by acute pain service personnel for quality of pain relief, using a rating scale that accounted for pain on movement. The presence of side effects and complications was assessed.
RESULTS: Data were collected from February 1990 to May 1993. The average duration of infusion was 3 days. A patient's pain relief was rated as good to excellent on 82.6% of visits. Side effects possibly attributable to fentanyl included sedation (7.4%), pruritus (10.2%), nausea and vomiting (3.1%), and respiratory depression (1.2%). Respiratory depression commonly was associated with sedation and was detected easily on the postsurgical ward, with only four patients requiring naloxone (0.4%). Side effects possibly related to bupivacaine included unpleasant sensory block (2.6%), significant lower limb motor block (3.0%), and hypotension (6.6%). There were two cases of epidural hematoma. Inflammation at the epidural catheter insertion site occurred in 3.8% (38), of which 42% (16) had some cutaneous purulence detected. There were no epidural space infections. Mechanical problems, including dislodgment of the catheter, accounted for 18.7% of infusion discontinuations within the first 72 h.
CONCLUSIONS: Postoperative epidural fentanyl/bupivacaine infusions are effective and can be managed readily in general postsurgical wards with minimal complications provided that appropriate patient observations are performed.

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Year:  1995        PMID: 7574052     DOI: 10.1097/00000542-199510000-00012

Source DB:  PubMed          Journal:  Anesthesiology        ISSN: 0003-3022            Impact factor:   7.892


  24 in total

1.  Operative anesthesia and pain control.

Authors:  Jeffrey N Winacoo; Justin A Maykel
Journal:  Clin Colon Rectal Surg       Date:  2009-02

2.  Antiemetic effects of midazolam added to fentanyl-ropivacaine patient-controlled epidural analgesia after subtotal gastrectomy: A prospective, randomized, double-blind, controlled trial.

Authors:  Sioh Kim; Jeongwon Seo; Younghoon Jeon
Journal:  Curr Ther Res Clin Exp       Date:  2010-10

3.  The safety of concurrent administration of opioids via epidural and intravenous routes for postoperative pain in pediatric oncology patients.

Authors:  Doralina L Anghelescu; Catherine E Ross; Linda L Oakes; Laura L Burgoyne
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4.  Preoperative epidural fentanyl reduces postoperative pain after upper abdominal surgery.

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Journal:  J Anesth       Date:  2007-08-01       Impact factor: 2.078

5.  Antinociceptive synergistic interaction between morphine and n omega-nitro 1-arginine methyl ester on thermal nociceptive tests in the rats.

Authors:  H Yamaguchi; H Naito
Journal:  Can J Anaesth       Date:  1996-09       Impact factor: 5.063

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Review 7.  Epidural anaesthesia and spinal haematoma.

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Review 8.  Postoperative pulmonary infections.

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9.  Impact of pregabalin on early phase post-thoracotomy pain compared with epidural analgesia.

Authors:  Noriyuki Matsutani; Hitoshi Dejima; Takashi Nakayama; Yusuke Takahashi; Hirofumi Uehara; Hisae Iinuma; Toshiya Harashima; Kazuki Anraku; Masafumi Kawamura
Journal:  J Thorac Dis       Date:  2017-10       Impact factor: 2.895

10.  Neurological adverse events following regional anesthesia administration.

Authors:  Christopher D Kent; Laurent Bollag
Journal:  Local Reg Anesth       Date:  2010-10-27
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