Literature DB >> 7573731

Patient-controlled analgesia and prolonged ileus after uncomplicated colectomy.

J G Petros1, R Realica, S Ahmad, E B Rimm, R J Robillard.   

Abstract

BACKGROUND: Because the duration of postoperative ileus after uncomplicated colon surgery has increased at our institution in the past 4 years, thereby prolonging length of hospital stay for some patients, we assessed several clinical factors to determine which were responsible for the increase. PATIENTS AND METHODS: We retrospectively studied a cohort of 358 patients who underwent uncomplicated colon resection to investigate risk factors for prolonged postoperative ileus. Postoperatively, all patients received an analgesic agent, delivered either intramuscularly (IM) or by patient-controlled analgesia (PCA) pump, until their postoperative ileus resolved, as indicated by the passage of flatus and tolerance of a clear liquid diet.
RESULTS: There was no significant relationship between the length of postoperative ileus patient age or gender, the operating time, or the type or amount of analgesic agent used postoperatively. A significantly larger proportion of the patients who received PCA than those given an IM agent had ileus at 7, 6, and 5 days after surgery (P < 0.0001 for all comparisons after controlling for confounding factors), however. Overall, the use of PCA was associated with a delay in return of normal bowel function of 0.9 days. Patients who underwent a right colectomy had a significantly shorter ileus than those who had other procedures.
CONCLUSIONS: Our findings indicate that the use of PCA after uncomplicated colectomy increases the risk of prolonged postoperative ileus. We suggest that the routine use of PCA after colon surgery be reevaluated.

Entities:  

Mesh:

Year:  1995        PMID: 7573731     DOI: 10.1016/s0002-9610(99)80306-7

Source DB:  PubMed          Journal:  Am J Surg        ISSN: 0002-9610            Impact factor:   2.565


  4 in total

1.  Preoperative risk factors for prolonged postoperative ileus after colorectal resection.

Authors:  Albert M Wolthuis; Gabriele Bislenghi; Maarten Lambrecht; Steffen Fieuws; Anthony de Buck van Overstraeten; Guy Boeckxstaens; André D'Hoore
Journal:  Int J Colorectal Dis       Date:  2017-04-25       Impact factor: 2.571

2.  A systematic review and meta-analysis of baseline risk factors for the development of postoperative ileus in patients undergoing gastrointestinal surgery.

Authors:  M J Lee; P Vaughan-Shaw; D Vimalachandran
Journal:  Ann R Coll Surg Engl       Date:  2019-12-20       Impact factor: 1.891

3.  The duration of postoperative ileus after elective colectomy is correlated to surgical specialization.

Authors:  Pascal Gervaz; Pascal Bucher; Andreas Scheiwiller; Béatrice Mugnier-Konrad; Philippe Morel
Journal:  Int J Colorectal Dis       Date:  2005-11-03       Impact factor: 2.571

4.  Alvimopan, a novel, peripherally acting mu opioid antagonist: results of a multicenter, randomized, double-blind, placebo-controlled, phase III trial of major abdominal surgery and postoperative ileus.

Authors:  Bruce G Wolff; Fabrizio Michelassi; Todd M Gerkin; Lee Techner; Kathie Gabriel; Wei Du; Bruce A Wallin
Journal:  Ann Surg       Date:  2004-10       Impact factor: 12.969

  4 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.