BACKGROUND AND PURPOSE: When blood flow to a brain region that has undergone an ischemic attack is reestablished, additional injury is to be expected from the reperfusion. The purpose of the study was to determine the effect of the intra-arterial injection of nimodipine at reperfusion on infarct volume in rats subjected to partially reversible focal neocortical ischemia. METHODS: Two groups of Long-Evans rats with transient bilateral common carotid artery occlusion and permanent middle cerebral artery occlusion were subjected to retrograde cannulation of the external carotid artery close to the carotid bifurcation to allow the administration of isotonic saline (group 1) or nimodipine solution (group 2) just before and during reperfusion. The estimate for the actual amount of infarcted cortex was calculated by the volume ratio between the spared cortex in the infarcted hemisphere and the total cortex of the contralateral hemisphere by means of a serological method based on the Cavalieri principle. RESULTS: The percentage of cortex that was infarcted in control rats was 63.8 +/- 3.1%, whereas nimodipine-treated rats exhibited a significantly smaller (P < .005) percentage of infarct volume (31.3 +/- 12.7%). CONCLUSIONS: Our data show that the intra-arterial injection of nimodipine just before and during reperfusion reduced neocortical infarct volume in rats subjected to partially reversible focal cerebral ischemia.
BACKGROUND AND PURPOSE: When blood flow to a brain region that has undergone an ischemic attack is reestablished, additional injury is to be expected from the reperfusion. The purpose of the study was to determine the effect of the intra-arterial injection of nimodipine at reperfusion on infarct volume in rats subjected to partially reversible focal neocortical ischemia. METHODS: Two groups of Long-Evans rats with transient bilateral common carotid artery occlusion and permanent middle cerebral artery occlusion were subjected to retrograde cannulation of the external carotid artery close to the carotid bifurcation to allow the administration of isotonic saline (group 1) or nimodipine solution (group 2) just before and during reperfusion. The estimate for the actual amount of infarcted cortex was calculated by the volume ratio between the spared cortex in the infarcted hemisphere and the total cortex of the contralateral hemisphere by means of a serological method based on the Cavalieri principle. RESULTS: The percentage of cortex that was infarcted in control rats was 63.8 +/- 3.1%, whereas nimodipine-treated rats exhibited a significantly smaller (P < .005) percentage of infarct volume (31.3 +/- 12.7%). CONCLUSIONS: Our data show that the intra-arterial injection of nimodipine just before and during reperfusion reduced neocortical infarct volume in rats subjected to partially reversible focal cerebral ischemia.
Authors: W-S Cho; H-S Kang; J E Kim; O-K Kwon; C W Oh; Y J Son; B J Know; C Jung; M H Hang Journal: Interv Neuroradiol Date: 2011-06-20 Impact factor: 1.610
Authors: Alessandra Biondi; Giuseppe K Ricciardi; Louis Puybasset; Lamine Abdennour; Marcello Longo; Jacques Chiras; Rémy Van Effenterre Journal: AJNR Am J Neuroradiol Date: 2004 Jun-Jul Impact factor: 3.825
Authors: Patricia Martínez-Sánchez; María Gutiérrez-Fernández; Blanca Fuentes; Jaime Masjuán; María Alonso de Leciñana Cases; Maria Elena Novillo-López; Exuperio Díez-Tejedor Journal: J Transl Med Date: 2014-08-03 Impact factor: 5.531