Literature DB >> 7569038

Chromosomal position effects and the modulation of transgene expression.

A J Clark1, P Bissinger, D W Bullock, S Damak, R Wallace, C B Whitelaw, F Yull.   

Abstract

Chromosomal position effects can influence strongly the transcription of foreign genes in transgenic animals. This results in low frequencies and levels of gene expression and, in some cases, in aberrant patterns of expression. Strategies for overcoming these effects are described with particular reference to their application in embryonic stem cells.

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Year:  1994        PMID： 7569038     DOI： 10.1071/rd9940589

Source DB:  PubMed          Journal:  Reprod Fertil Dev        ISSN： 1031-3613            Impact factor:   2.311


  36 in total

Review 1.  The mammary gland as a bioreactor: expression, processing, and production of recombinant proteins.

Authors:  A J Clark
Journal:  J Mammary Gland Biol Neoplasia       Date:  1998-07       Impact factor: 2.673

2.  Pre-selection of integration sites imparts repeatable transgene expression.

Authors:  H Wallace; R Ansell; J Clark; J McWhir
Journal:  Nucleic Acids Res       Date:  2000-03-15       Impact factor: 16.971

3.  Characterization and functional analysis of the 5'-flanking promoter region of the mouse Tcf3 gene.

Authors:  Nina Solberg; Ondrej Machon; Stefan Krauss
Journal:  Mol Cell Biochem       Date:  2011-09-21       Impact factor: 3.396

4.  Development of a BAC vector for integration-independent and tight regulation of transgenes in rodents via the Tet system.

Authors:  Kai Schönig; David Kentner; Manfred Gossen; Tina Baldinger; Jun Miao; Katrin Welzel; Andreas Vente; Dusan Bartsch; Hermann Bujard
Journal:  Transgenic Res       Date:  2010-07-18       Impact factor: 2.788

5.  Site-directed mutagenesis of the Arabidopsis heterotrimeric G protein β subunit suggests divergent mechanisms of effector activation between plant and animal G proteins.

Authors:  David Chakravorty; Yuri Trusov; José Ramón Botella
Journal:  Planta       Date:  2011-10-15       Impact factor: 4.116

Review 6.  Animal transgenesis: state of the art and applications.

Authors:  Eduardo O Melo; Aurea M O Canavessi; Mauricio M Franco; Rodolfo Rumpf
Journal:  J Appl Genet       Date:  2007       Impact factor: 3.240

7.  The changing role of cell culture in the generation of transgenic livestock.

Authors:  C B Whitelaw; E Farini; J Webster
Journal:  Cytotechnology       Date:  1999-09       Impact factor: 2.058

8.  Direct introduction of gene constructs into the pronucleus-like structure of cloned embryos: a new strategy for the generation of genetically modified pigs.

Authors:  Mayuko Kurome; Simon Leuchs; Barbara Kessler; Elisabeth Kemter; Eva-Maria Jemiller; Beatrix Foerster; Nikolai Klymiuk; Valeri Zakhartchenko; Eckhard Wolf
Journal:  Transgenic Res       Date:  2016-12-10       Impact factor: 2.788

9.  hVGAT-mCherry: A novel molecular tool for analysis of GABAergic neurons derived from human pluripotent stem cells.

Authors:  Brooke A DeRosa; Kinsley C Belle; Blake J Thomas; Holly N Cukier; Margaret A Pericak-Vance; Jeffery M Vance; Derek M Dykxhoorn
Journal:  Mol Cell Neurosci       Date:  2015-08-16       Impact factor: 4.314

10.  Lentiviral integration preferences in transgenic mice.

Authors:  Shang-Hsun Yang; Pei-Hsun Cheng; Robert T Sullivan; James W Thomas; Anthony W S Chan
Journal:  Genesis       Date:  2008-12       Impact factor: 2.487
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