Literature DB >> 7568169

Signaling by ABL oncogenes through cyclin D1.

D E Afar1, J McLaughlin, C J Sherr, O N Witte, M F Roussel.   

Abstract

Oncogenic signals induce cellular proliferation by deregulating the cell division cycle. Cyclin D1, a regulator of G1-phase progression, acts synergistically with ABL oncogenes in transforming fibroblasts and hematopoietic cells in culture. Synergy with v-Abl depended on a motif in cyclin D1 that mediates its binding to the retinoblastoma protein, suggesting that ABL oncogenes in part mediate their mitogenic effects via a retinoblastoma protein-dependent pathway. Overexpression of cyclin D1, but not cyclin E, rescued a signaling-defective src-homology 2 (SH2) domain mutant of BCR-ABL for transformation of cells in culture and malignant tumor formation in vivo. These results demonstrate that cyclin D1 can provide essential signals for malignant transformation in concert with an activated tyrosine kinase.

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Year:  1995        PMID： 7568169      PMCID： PMC40837          DOI： 10.1073/pnas.92.21.9540

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  56 in total

1.  Formation and activation of a cyclin E-cdk2 complex during the G1 phase of the human cell cycle.

Authors:  A Koff; A Giordano; D Desai; K Yamashita; J W Harper; S Elledge; T Nishimoto; D O Morgan; B R Franza; J M Roberts
Journal:  Science       Date:  1992-09-18       Impact factor: 47.728

2.  Direct binding of cyclin D to the retinoblastoma gene product (pRb) and pRb phosphorylation by the cyclin D-dependent kinase CDK4.

Authors:  J Kato; H Matsushime; S W Hiebert; M E Ewen; C J Sherr
Journal:  Genes Dev       Date:  1993-03       Impact factor: 11.361

3.  Cyclins D1 and D2 are differentially expressed in human B-lymphoid cell lines.

Authors:  I Palmero; A Holder; A J Sinclair; C Dickson; G Peters
Journal:  Oncogene       Date:  1993-04       Impact factor: 9.867

4.  Efficient transplantation of BCR-ABL-induced chronic myelogenous leukemia-like syndrome in mice.

Authors:  M L Gishizky; J Johnson-White; O N Witte
Journal:  Proc Natl Acad Sci U S A       Date:  1993-04-15       Impact factor: 11.205

5.  Functional interactions of the retinoblastoma protein with mammalian D-type cyclins.

Authors:  M E Ewen; H K Sluss; C J Sherr; H Matsushime; J Kato; D M Livingston
Journal:  Cell       Date:  1993-05-07       Impact factor: 41.582

6.  Identification and properties of an atypical catalytic subunit (p34PSK-J3/cdk4) for mammalian D type G1 cyclins.

Authors:  H Matsushime; M E Ewen; D K Strom; J Y Kato; S K Hanks; M F Roussel; C J Sherr
Journal:  Cell       Date:  1992-10-16       Impact factor: 41.582

7.  Independent regulation of human D-type cyclin gene expression during G1 phase in primary human T lymphocytes.

Authors:  F Ajchenbaum; K Ando; J A DeCaprio; J D Griffin
Journal:  J Biol Chem       Date:  1993-02-25       Impact factor: 5.157

8.  Differential modulation of cyclin gene expression by MYC.

Authors:  P Jansen-Dürr; A Meichle; P Steiner; M Pagano; K Finke; J Botz; J Wessbecher; G Draetta; M Eilers
Journal:  Proc Natl Acad Sci U S A       Date:  1993-04-15       Impact factor: 11.205

9.  Cyclin-dependent regulation of G1 in mammalian fibroblasts.

Authors:  M Ohtsubo; J M Roberts
Journal:  Science       Date:  1993-03-26       Impact factor: 47.728

10.  Cyclin D1/bcl-1 cooperates with myc genes in the generation of B-cell lymphoma in transgenic mice.

Authors:  H Lovec; A Grzeschiczek; M B Kowalski; T Möröy
Journal:  EMBO J       Date:  1994-08-01       Impact factor: 11.598
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  14 in total

1.  Transformation of hematopoietic cells by BCR/ABL requires activation of a PI-3k/Akt-dependent pathway.

Authors:  T Skorski; A Bellacosa; M Nieborowska-Skorska; M Majewski; R Martinez; J K Choi; R Trotta; P Wlodarski; D Perrotti; T O Chan; M A Wasik; P N Tsichlis; B Calabretta
Journal:  EMBO J       Date:  1997-10-15       Impact factor: 11.598

2.  Plasmacytomagenesis in Eμ-v-abl transgenic mice is accelerated when apoptosis is restrained.

Authors:  Cassandra J Vandenberg; Paul Waring; Andreas Strasser; Suzanne Cory
Journal:  Blood       Date:  2014-07-01       Impact factor: 22.113

3.  BCR-ABL induces tyrosine phosphorylation of YAP leading to expression of Survivin and Cyclin D1 in chronic myeloid leukemia cells.

Authors:  Kenta Moriyama; Toshiyuki Hori
Journal:  Int J Hematol       Date:  2019-08-19       Impact factor: 2.490

4.  Complementation of growth factor receptor-dependent mitogenic signaling by a truncated type I phosphatidylinositol 4-phosphate 5-kinase.

Authors:  J N Davis; C O Rock; M Cheng; J B Watson; R A Ashmun; H Kirk; R J Kay; M F Roussel
Journal:  Mol Cell Biol       Date:  1997-12       Impact factor: 4.272

5.  Repositioning antispasmodic drug Papaverine for the treatment of chronic myeloid leukemia.

Authors:  Phani Krishna Parcha; Sailu Sarvagalla; Cheemala Ashok; S J Sudharshan; Madhu Dyavaiah; Mohane Selvaraj Coumar; Baskaran Rajasekaran
Journal:  Pharmacol Rep       Date:  2021-01-03       Impact factor: 3.024

6.  Protein binding and signaling properties of RIN1 suggest a unique effector function.

Authors:  L Han; D Wong; A Dhaka; D Afar; M White; W Xie; H Herschman; O Witte; J Colicelli
Journal:  Proc Natl Acad Sci U S A       Date:  1997-05-13       Impact factor: 11.205

7.  Sole BCR-ABL inhibition is insufficient to eliminate all myeloproliferative disorder cell populations.

Authors:  S Wong; J McLaughlin; D Cheng; C Zhang; K M Shokat; O N Witte
Journal:  Proc Natl Acad Sci U S A       Date:  2004-10-25       Impact factor: 11.205

Review 8.  Molecular biology of chronic myeloid leukemia.

Authors:  Y Maru
Journal:  Int J Hematol       Date:  2001-04       Impact factor: 2.490

9.  NF-kappaB1 can inhibit v-Abl-induced lymphoid transformation by functioning as a negative regulator of cyclin D1 expression.

Authors:  Yukio Nakamura; Raelene J Grumont; Steve Gerondakis
Journal:  Mol Cell Biol       Date:  2002-08       Impact factor: 4.272

10.  Inhibition of tumor growth and metastasis by non-small cell lung cancer cells transfected with cyclin D1-targeted siRNA.

Authors:  Hu Huang; Yi-de Hu; Na Li; Yong Zhu
Journal:  Oligonucleotides       Date:  2009-06
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