| Literature DB >> 7562986 |
Y Hirakata1, N Furuya, K Tateda, T Matsumoto, K Yamaguchi.
Abstract
The role of Pseudomonas aeruginosa exo-enzymes was evaluated in a murine model of endogenous bacteraemia in which the bacteria invaded the bloodstream after oral dosing. Although an elastase mutant PAO-E64 was as virulent as its parent strain PAO1, an exo-enzyme S-deficient mutant, DG1-ExS5 and alkaline protease mutants PAKS-16, PAKS-17, PAKS-19, were less virulent than their parent strains, DG1 and PAKS-1, respectively (p < 0.01). Thus exo-enzyme S and alkaline protease, but not elastase, appear to contribute to the pathogenicity of P. aeruginosa in this model.Entities:
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Year: 1995 PMID： 7562986 DOI： 10.1099/00222615-43-4-258
Source DB: PubMed Journal: J Med Microbiol ISSN： 0022-2615 Impact factor: 2.472