Literature DB >> 7562950

1-(Fluorobenzyl)-4-amino-1H-1,2,3-triazolo[4,5-c]pyridines: synthesis and anticonvulsant activity.

J L Kelley1, C S Koble, R G Davis, E W McLean, F E Soroko, B R Cooper.   

Abstract

A series of (fluorobenzyl)triazolo[4,5-c]pyridines was synthesized and tested for activity against maximal electroshock-induced seizures in rodents. The most promising compound, 14 (BW 534U87), which is a carbon-nitrogen isoster of a purine anticonvulsant, has a profile in rodents that suggests 14 will be free of emesis and useful in the treatment of seizure disorders for which phenytoin is presently indicated.

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Year:  1995        PMID： 7562950     DOI： 10.1021/jm00020a030

Source DB:  PubMed          Journal:  J Med Chem        ISSN： 0022-2623            Impact factor:   7.446


  5 in total

1.  The anticonvulsant BW534U87 depresses epileptiform activity in rat hippocampal slices by an adenosine-dependent mechanism and through inhibition of voltage-gated Na+ channels.

Authors:  J R Dupere; T J Dale; S J Starkey; X Xie
Journal:  Br J Pharmacol       Date:  1999-11       Impact factor: 8.739

2.  Design and synthesis of substituted (1-(benzyl)-1H-1,2,3-triazol-4-yl)(piperazin-1-yl)methanone conjugates: study on their apoptosis inducing ability and tubulin polymerization inhibition.

Authors:  Kesari Lakshmi Manasa; Sowjanya Thatikonda; Dilep Kumar Sigalapalli; Sowmya Vuppaladadium; Ganthala Parimala Devi; Chandraiah Godugu; Mallika Alvala; Narayana Nagesh; Bathini Nagendra Babu
Journal:  RSC Med Chem       Date:  2020-09-08

3.  Synthesis, molecular docking, and biological evaluation of Schiff base hybrids of 1,2,4-triazole-pyridine as dihydrofolate reductase inhibitors.

Authors:  D Dewangan; Y Vaishnav; A Mishra; A K Jha; S Verma; H Badwaik
Journal:  Curr Res Pharmacol Drug Discov       Date:  2021-04-15

4.  Design, synthesis, molecular-docking and antimycobacterial evaluation of some novel 1,2,3-triazolyl xanthenones.

Authors:  Gudikadi Linga Goud; Seela Ramesh; Dongamanti Ashok; Vummenthala Prabhakar Reddy; Perumal Yogeeswari; Dharmarajan Sriram; Balabadra Saikrishna; Vijjulatha Manga
Journal:  Medchemcomm       Date:  2017-01-03       Impact factor: 3.597

5.  Design, Synthesis, and the Biological Evaluation of a New Series of Acyclic 1,2,3-Triazole Nucleosides.

Authors:  Iwona E Głowacka; Graciela Andrei; Dominique Schols; Robert Snoeck; Katarzyna Gawron
Journal:  Arch Pharm (Weinheim)       Date:  2017-08-01       Impact factor: 3.751
  5 in total

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