Literature DB >> 7561677

Penetration of the blood-brain barrier: enhancement of drug delivery and imaging by bacterial glycopeptides.

B Spellerberg1, S Prasad, C Cabellos, M Burroughs, P Cahill, E Tuomanen.   

Abstract

The blood-brain barrier restricts the passage of many pharmacological agents into the brain parenchyma. Bacterial glycopeptides induce enhanced blood-brain barrier permeability when they are present in the subarachnoid space during meningitis. By presenting such glycopeptides intravenously, blood-brain barrier permeability in rabbits was enhanced in a reversible time- and dose-dependent manner to agents < or = 20 kD in size. Therapeutic application of this bioactivity was evident as enhanced penetration of the antibiotic penicillin and the magnetic resonance imaging contrast agent gadolinium-diethylene-triamine-pentaacetic acid into the brain parenchyma.

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Year:  1995        PMID： 7561677      PMCID： PMC2192296          DOI： 10.1084/jem.182.4.1037

Source DB:  PubMed          Journal:  J Exp Med        ISSN： 0022-1007            Impact factor:   14.307


  12 in total

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Authors:  V Quagliarello; W M Scheld
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Review 2.  Permeability of the blood-brain barrier to peptides: an approach to the development of therapeutically useful analogs.

Authors:  W A Banks; K L Audus; T P Davis
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5.  Bacterial peptidoglycans as modulators of sleep. II. Effects of muramyl peptides on the structure of rabbit sleep.

Authors:  J M Krueger; D Davenne; J Walter; S Shoham; S L Kubillus; R S Rosenthal; S A Martin; K Biemann
Journal:  Brain Res       Date:  1987-02-17       Impact factor: 3.252

6.  Haemophilus influenzae lipopolysaccharide-induced blood brain barrier permeability during experimental meningitis in the rat.

Authors:  B Wispelwey; A J Lesse; E J Hansen; W M Scheld
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7.  A structure-activity relationship for induction of meningeal inflammation by muramyl peptides.

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3.  Phosphatidylcholine-specific phospholipase C from Listeria monocytogenes is an important virulence factor in murine cerebral listeriosis.

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Review 4.  Infection-induced inflammation and cerebral injury in preterm infants.

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5.  Pneumococcal trafficking across the blood-brain barrier. Molecular analysis of a novel bidirectional pathway.

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