| Literature DB >> 7561532 |
J L Ambrus1, S Stadler, M Kulaylat.
Abstract
Pentoxifylline (Trental) is metabolized by red blood cells and the liver into seven metabolites. Metabolites I and V have significant hemorrheologic effects. They are both similar to pentoxifylline in their activity on red blood cell membrane fluidity. Metabolite I is more active than pentoxifylline in inhibiting ADP-induced platelet aggregation. Metabolite V is more active than pentoxifylline in inhibiting epinephrine-induced platelet aggregation.Entities:
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Year: 1995 PMID： 7561532
Source DB: PubMed Journal: J Med ISSN： 0025-7850