Literature DB >> 7560742

Effect of s-triazine compounds on testosterone metabolism in the rat prostate.

J Kniewald1, V Osredecki, T Gojmerac, V Zechner, Z Kniewald.   

Abstract

The influence of s-triazine compounds (atrazine, prometryne and deethylatrazine) on testosterone conversion and 5 alpha-dihydrotestosterone-receptor complex formation was studied in vitro and in vivo in the rat prostate. A marked in vitro influence of atrazine and prometryne (from 0.465 to 1.392 mumol) and their mixtures (in total concentration, 0.928 mumol) on 5 alpha-dihydrotestosterone formation was detected. 5 alpha-Dihydrotestosterone-specific receptor complex formation was inhibited in vitro by ca. 0.5 mumol of atrazine or deethylatrazine and only in vivo by 6 mg of atrazine 100 g-1 body wt. daily during 7 days in the prostate cytosol. The inhibition of the enzymic activities responsible for testosterone conversion and steroid hormone-receptor complex formation was non-competitive and reversible, and s-triazine compounds act as antiandrogens.

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Year:  1995        PMID： 7560742     DOI： 10.1002/jat.2550150312

Source DB:  PubMed          Journal:  J Appl Toxicol        ISSN： 0260-437X            Impact factor:   3.446


  11 in total

Review 1.  Demasculinization and feminization of male gonads by atrazine: consistent effects across vertebrate classes.

Authors:  Tyrone B Hayes; Lloyd L Anderson; Val R Beasley; Shane R de Solla; Taisen Iguchi; Holly Ingraham; Patrick Kestemont; Jasna Kniewald; Zlatko Kniewald; Valerie S Langlois; Enrique H Luque; Krista A McCoy; Mónica Muñoz-de-Toro; Tomohiro Oka; Cleida A Oliveira; Frances Orton; Sylvia Ruby; Miyuki Suzawa; Luz E Tavera-Mendoza; Vance L Trudeau; Anna Bolivar Victor-Costa; Emily Willingham
Journal:  J Steroid Biochem Mol Biol       Date:  2011-03-23       Impact factor: 4.292

2.  Atrazine induces penis abnormalities including hypospadias in mice.

Authors:  Luke C Govers; Alesia P Harper; Bethany J Finger; Deidre M Mattiske; Andrew J Pask; Mark P Green
Journal:  J Dev Orig Health Dis       Date:  2019-09-02       Impact factor: 2.401

3.  Hermaphroditic, demasculinized frogs after exposure to the herbicide atrazine at low ecologically relevant doses.

Authors:  Tyrone B Hayes; Atif Collins; Melissa Lee; Magdelena Mendoza; Nigel Noriega; A Ali Stuart; Aaron Vonk
Journal:  Proc Natl Acad Sci U S A       Date:  2002-04-16       Impact factor: 11.205

4.  High doses of atrazine do not disrupt activity and expression of aromatase in female gonads of juvenile goldfish (Carassius auratus L.).

Authors:  S Nadzialek; L Spanò; S N M Mandiki; P Kestemont
Journal:  Ecotoxicology       Date:  2008-02-20       Impact factor: 2.823

5.  Characterization of atrazine-induced gonadal malformations in African clawed frogs (Xenopus laevis) and comparisons with effects of an androgen antagonist (cyproterone acetate) and exogenous estrogen (17beta-estradiol): Support for the demasculinization/feminization hypothesis.

Authors:  Tyrone B Hayes; A Ali Stuart; Magdalena Mendoza; Atif Collins; Nigel Noriega; Aaron Vonk; Gwynne Johnston; Roger Liu; Dzifa Kpodzo
Journal:  Environ Health Perspect       Date:  2006-04       Impact factor: 9.031

6.  Atrazine in sub-acute exposure results in sperm DNA disintegrity and nuclear immaturity in rats.

Authors:  Sajad Feyzi-Dehkhargani; Rasoul Shahrooz; Hassan Malekinejad; Rajab-Ali Sadrkhanloo
Journal:  Vet Res Forum       Date:  2012       Impact factor: 1.054

7.  Chronic Atrazine Exposure Beginning Prenatally Impacts Liver Function and Sperm Concentration With Multi-Generational Consequences in Mice.

Authors:  Alesia P Harper; Bethany J Finger; Mark P Green
Journal:  Front Endocrinol (Lausanne)       Date:  2020-11-26       Impact factor: 5.555

8.  G-protein-coupled receptor 30 and estrogen receptor-alpha are involved in the proliferative effects induced by atrazine in ovarian cancer cells.

Authors:  Lidia Albanito; Rosamaria Lappano; Antonio Madeo; Adele Chimento; Eric R Prossnitz; Anna Rita Cappello; Vincenza Dolce; Sergio Abonante; Vincenzo Pezzi; Marcello Maggiolini
Journal:  Environ Health Perspect       Date:  2008-07-22       Impact factor: 9.031

9.  Semen quality in relation to biomarkers of pesticide exposure.

Authors:  Shanna H Swan; Robin L Kruse; Fan Liu; Dana B Barr; Erma Z Drobnis; J Bruce Redmon; Christina Wang; Charlene Brazil; James W Overstreet
Journal:  Environ Health Perspect       Date:  2003-09       Impact factor: 9.031

10.  Atrazine-induced aromatase expression is SF-1 dependent: implications for endocrine disruption in wildlife and reproductive cancers in humans.

Authors:  WuQiang Fan; Toshihiko Yanase; Hidetaka Morinaga; Shigeki Gondo; Taijiro Okabe; Masatoshi Nomura; Tomoko Komatsu; Ken-Ichirou Morohashi; Tyrone B Hayes; Ryoichi Takayanagi; Hajime Nawata
Journal:  Environ Health Perspect       Date:  2007-02-05       Impact factor: 9.031
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