Self-activation of N-phosphoamino acids and N-phosphodipeptides in oligopeptide formation.

N-Phosphorylamino acids and N-phosphoryldipeptides can self-activate to give the oligopeptide. An intramolecular mixed anhydride intermediate might exist during the self-activating process. A peptide bond was formed from the N-terminus to the C-terminus by the '1 + n' mechanism, which was similar to the rRNA-peptide biosynthesis pathway.