Literature DB >> 7558006

Mapping of the gene for the Mel1a-melatonin receptor to human chromosome 4 (MTNR1A) and mouse chromosome 8 (Mtnr1a).

S A Slaugenhaupt1, A L Roca, C B Liebert, M R Altherr, J F Gusella, S M Reppert.   

Abstract

The pineal hormone melatonin elicits potent circadian and reproductive effects in mammals. We report the chromosomal location of the gene for the Mel1a-melatonin receptor that likely mediates these circadian and reproductive actions. PCR analysis of human-rodent somatic cell hybrids showed that the receptor gene (MTNR1A) maps to human chromosome 4q35.1. An interspecific backcross analysis revealed that the mouse gene (Mtnr1a) maps to the proximal portion of chromosome 8. These loci may be involved in genetically based circadian and neuroendocrine disorders.

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Year:  1995        PMID： 7558006     DOI： 10.1006/geno.1995.1056

Source DB:  PubMed          Journal:  Genomics        ISSN： 0888-7543            Impact factor:   5.736


  17 in total

1.  The Ant1 gene maps near Klk3 on proximal mouse chromosome 8.

Authors:  K A Mills; J W Ellison; K D Mathews
Journal:  Mamm Genome       Date:  1996-09       Impact factor: 2.957

Review 2.  MT1 and MT2 Melatonin Receptors: A Therapeutic Perspective.

Authors:  Jiabei Liu; Shannon J Clough; Anthony J Hutchinson; Ekue B Adamah-Biassi; Marina Popovska-Gorevski; Margarita L Dubocovich
Journal:  Annu Rev Pharmacol Toxicol       Date:  2015-10-23       Impact factor: 13.820

3.  Mapping of the melatonin receptor 1a (MTNR1A) gene in pigs, sheep, and cattle.

Authors:  L A Messer; L Wang; C K Tuggle; M Yerle; P Chardon; D Pomp; J E Womack; W Barendse; A M Crawford; D R Notter; M F Rothschild
Journal:  Mamm Genome       Date:  1997-05       Impact factor: 2.957

4.  Distribution of MT1 melatonin receptor promoter-driven RFP expression in the brains of BAC C3H/HeN transgenic mice.

Authors:  E B Adamah-Biassi; Y Zhang; H Jung; S Vissapragada; R J Miller; M l Dubocovich
Journal:  J Histochem Cytochem       Date:  2013-09-18       Impact factor: 2.479

5.  WDL-RF: predicting bioactivities of ligand molecules acting with G protein-coupled receptors by combining weighted deep learning and random forest.

Authors:  Jiansheng Wu; Qiuming Zhang; Weijian Wu; Tao Pang; Haifeng Hu; Wallace K B Chan; Xiaoyan Ke; Yang Zhang
Journal:  Bioinformatics       Date:  2018-07-01       Impact factor: 6.937

Review 6.  Functional MT1 and MT2 melatonin receptors in mammals.

Authors:  Margarita L Dubocovich; Magdalena Markowska
Journal:  Endocrine       Date:  2005-07       Impact factor: 3.633

7.  12-year-old boy with a 4q35.2 microdeletion and involvement of MTNR1A, FAT1, and F11 genes.

Authors:  Erin L Youngs; Rebecca S Henkhaus; Jessica A Hellings; Merlin G Butler
Journal:  Clin Dysmorphol       Date:  2012-04       Impact factor: 0.816

8.  International Union of Basic and Clinical Pharmacology. LXXV. Nomenclature, classification, and pharmacology of G protein-coupled melatonin receptors.

Authors:  Margarita L Dubocovich; Philippe Delagrange; Diana N Krause; David Sugden; Daniel P Cardinali; James Olcese
Journal:  Pharmacol Rev       Date:  2010-07-06       Impact factor: 25.468

9.  MT1 melatonin receptor expression in Warthin's tumor.

Authors:  Jose Aneiros-Fernandez; Salvador Arias-Santiago; Borja Arias-Santiago; Maria Herrero-Fernández; V Carriel; Jose Aneiros-Cachaza; Antonio López-Valverde; Antonio Cutando-Soriano
Journal:  Pathol Oncol Res       Date:  2012-10-17       Impact factor: 3.201

Review 10.  Pharmacology of ramelteon, a selective MT1/MT2 receptor agonist: a novel therapeutic drug for sleep disorders.

Authors:  Masaomi Miyamoto
Journal:  CNS Neurosci Ther       Date:  2009       Impact factor: 5.243
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