Literature DB >> 7558005

Structure and chromosomal localization of a human water channel (AQP3) gene.

K Ishibashi1, S Sasaki, F Saito, T Ikeuchi, F Marumo.   

Abstract

A cDNA encoding rat AQP3, a water channel and a member of the MIP family, that is expressed predominantly in kidney medulla and colon was cloned recently. To determine the structure, tissue distribution, and chromosomal localization of the human AQP3 gene, we screened a human kidney cDNA library with rat AQP3 probe and isolated a cDNA coding for human AQP3 protein. The deduced amino acid sequence of human AQP3 was 91% identical to rat AQP3. Human AQP3 mRNA was expressed in colon, kidney, liver, pancreas, lung, peripheral leukocytes, spleen, and prostate. The human AQP3 gene was mapped to 7q36.2-q36.3 by chromosome fluorescence in situ hybridization.

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Year:  1995        PMID： 7558005     DOI： 10.1006/geno.1995.1055

Source DB:  PubMed          Journal:  Genomics        ISSN： 0888-7543            Impact factor:   5.736


  19 in total

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Review 10.  Aquaporins in the Colon as a New Therapeutic Target in Diarrhea and Constipation.

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