Literature DB >> 7557405

The 3'-untranslated regions from the Trypanosoma brucei phosphoglycerate kinase-encoding genes mediate developmental regulation.

J Blattner1, C E Clayton.   

Abstract

The phosphoglycerate kinase (PGK)-encoding genes of Trypanosoma brucei are transcribed in a polycistronic fashion, but the mRNAs encoding the three PGK isozymes show differing developmental regulation. We demonstrate here that the 3'-untranslated regions of the major cytoplasmic and glycosomal PGK isozymes are capable of conferring the anticipated types of regulation on a transfected reporter gene.

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Year:  1995        PMID： 7557405     DOI： 10.1016/0378-1119(95)00366-e

Source DB:  PubMed          Journal:  Gene        ISSN： 0378-1119            Impact factor:   3.688


  22 in total

1.  Degradation of the unstable EP1 mRNA in Trypanosoma brucei involves initial destruction of the 3'-untranslated region.

Authors:  H Irmer; C Clayton
Journal:  Nucleic Acids Res       Date:  2001-11-15       Impact factor: 16.971

Review 2.  Life without transcriptional control? From fly to man and back again.

Authors:  Christine E Clayton
Journal:  EMBO J       Date:  2002-04-15       Impact factor: 11.598

3.  The DNA sequence of chromosome I of an African trypanosome: gene content, chromosome organisation, recombination and polymorphism.

Authors:  Neil Hall; Matthew Berriman; Nicola J Lennard; Barbara R Harris; Christiane Hertz-Fowler; Emmanuelle N Bart-Delabesse; Caroline S Gerrard; Rebecca J Atkin; Andrew J Barron; Sharen Bowman; Sarah P Bray-Allen; Frédéric Bringaud; Louise N Clark; Craig H Corton; Ann Cronin; Robert Davies; Jonathon Doggett; Audrey Fraser; Eric Grüter; Sarah Hall; A David Harper; Mike P Kay; Vanessa Leech; Rebecca Mayes; Claire Price; Michael A Quail; Ester Rabbinowitsch; Christopher Reitter; Kim Rutherford; Jürgen Sasse; Sarah Sharp; Ratna Shownkeen; Annette MacLeod; Sonya Taylor; Alison Tweedie; C Michael R Turner; Andrew Tait; Keith Gull; Bart Barrell; Sara E Melville
Journal:  Nucleic Acids Res       Date:  2003-08-15       Impact factor: 16.971

4.  A novel strategy to identify the location of necessary and sufficient cis-acting regulatory mRNA elements in trypanosomes.

Authors:  Helena Webb; Roisin Burns; Nicola Kimblin; Louise Ellis; Mark Carrington
Journal:  RNA       Date:  2005-05-31       Impact factor: 4.942

5.  Compartmentation prevents a lethal turbo-explosion of glycolysis in trypanosomes.

Authors:  Jurgen R Haanstra; Arjen van Tuijl; Peter Kessler; Willem Reijnders; Paul A M Michels; Hans V Westerhoff; Marilyn Parsons; Barbara M Bakker
Journal:  Proc Natl Acad Sci U S A       Date:  2008-11-13       Impact factor: 11.205

6.  Compartmentation of phosphoglycerate kinase in Trypanosoma brucei plays a critical role in parasite energy metabolism.

Authors:  J Blattner; S Helfert; P Michels; C Clayton
Journal:  Proc Natl Acad Sci U S A       Date:  1998-09-29       Impact factor: 11.205

7.  Genome-wide analysis reveals distinct substrate specificities of Rrp6, Dis3, and core exosome subunits.

Authors:  Daniel L Kiss; Erik D Andrulis
Journal:  RNA       Date:  2010-02-25       Impact factor: 4.942

8.  The RNA helicase DHH1 is central to the correct expression of many developmentally regulated mRNAs in trypanosomes.

Authors:  Susanne Kramer; Rafael Queiroz; Louise Ellis; Jörg D Hoheisel; Christine Clayton; Mark Carrington
Journal:  J Cell Sci       Date:  2010-02-02       Impact factor: 5.285

9.  Mechanisms of developmental regulation in Trypanosoma brucei: a polypyrimidine tract in the 3'-untranslated region of a surface protein mRNA affects RNA abundance and translation.

Authors:  H R Hotz; C Hartmann; K Huober; M Hug; C Clayton
Journal:  Nucleic Acids Res       Date:  1997-08-01       Impact factor: 16.971

10.  Roles of a Trypanosoma brucei 5'->3' exoribonuclease homolog in mRNA degradation.

Authors:  Chi-Ho Li; Henriette Irmer; Drifa Gudjonsdottir-Planck; Simone Freese; Heike Salm; Simon Haile; Antonio M Estévez; Christine Clayton
Journal:  RNA       Date:  2006-10-31       Impact factor: 4.942
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