| Literature DB >> 7556648 |
T Moriyama1, H Kataoka, H Tsubouchi, M Koono.
Abstract
Three new cell lines of human glioblastoma have been established. These cells co-expressed hepatocyte growth factor (HGF) and its receptor, c-Met, genes in vitro. Reverse-transcriptase/polymerase-chain reaction study revealed that the cells also expressed gene for HGF activator, a recently cloned serine proteinase, suggesting that HGF might have a role in glioma cells in vitro as an autocrine factor. The activator mRNA was also detected in other well-established glioma cell lines, glioma tissues and normal brain. The concomitant expression of HGF, HGF activator and c-met was also detected in one glioblastoma case in vivo out of five tested.Entities:
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Year: 1995 PMID： 7556648 DOI： 10.1016/0014-5793(95)00949-a
Source DB: PubMed Journal: FEBS Lett ISSN： 0014-5793 Impact factor: 4.124