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Literature DB >> 7556578

Pentoxifylline attenuates acute lung injury induced by microemboli.

Abstract

Pentoxifylline (PTX), a methylxanthine derivative, effectively prevents acute lung injury in different animal models. To investigate whether PTX would attenuate acute lung injury induced by microemboli resulting from treatment with calcium chloride (CaCl2) suspension, an isolated blood-perfused rat lung model was used. Pretreatment with PTX prevented the increase in pulmonary arterial pressure (PAP), lung weight gain and protein concentration in the lavage fluid after CaCl2 treatment.

Entities: Chemical Disease Species

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Year: 1995 PMID： 7556578 DOI： 10.1007/bf01921747

Source DB: PubMed Journal: Experientia ISSN： 0014-4754

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References

24 in total

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Authors: H R Dettelbach; D M Aviado
Journal: J Clin Pharmacol Date: 1985 Jan-Feb Impact factor: 3.126

Pentoxifylline attenuates acute lung injury induced by microemboli.

1. Adult respiratory distress syndrome: early predictors of mortality.

Review 2. ARDS, neutrophils, and pentoxifylline.

3. Lung pathology in respiratory distress following shock in the adult.

4. Consumption coagulopathy in the canine oleic acid model of fat embolism.

Review 5. Clinical pharmacology of pentoxifylline with special reference to its hemorrheologic effect for the treatment of intermittent claudication.

6. Pulmonary platelet deposition accompanying acute oleic-acid-induced pulmonary injury.

7. Attenuation of acute lung injury in septic guinea pigs by pentoxifylline.

8. Protamine-induced acute lung injury and the protective effect of agents that increase cAMP.

9. Cyclooxygenase pathway mediates lung injury induced by phorbol and platelets.

10. Pentoxifylline does not attenuate acute lung injury in the absence of granulocytes.