Literature DB >> 7556575

The influence of prostacyclin (PGI2) on contractile properties of isolated right ventricle of rat heart.

M Pavlović1, D Petković, M Cvetković, D J Macut, K Zdjelar, M Nesić, O Bosnić, R Radulović, M Mihajlović.   

Abstract

The mechanism of the positive inotropic effect of prostacyclin (PGI2) (2.6 x 10(-6) mol/l) on the isolated right ventricle of rat heart was studied. Our results show that the positive inotropic effect of prostacyclin is produced indirectly through beta adrenoceptors and slow Ca2+ channels, because blockade of slow Ca2+ channels with verapamil (10(-6) mol/l) and beta adrenoceptors with propranolol (10(-6) mol/l) abolishes this effect. Alpha adrenoceptors do not mediate the action of PGI2.

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Year:  1995        PMID： 7556575     DOI： 10.1007/bf01921744

Source DB:  PubMed          Journal:  Experientia        ISSN： 0014-4754


  18 in total

1.  Prostaglandin I2 (PGI2) enhances calcium current in guinea-pig ventricular heart cells.

Authors:  G Alloatti; L Serazzi; R C Levi
Journal:  J Mol Cell Cardiol       Date:  1991-07       Impact factor: 5.000

Review 2.  Prostacyclin and its clinical applications.

Authors:  S Moncada; J R Vane
Journal:  Ann Clin Res       Date:  1984

3.  Effect of prostaglandins on rat heart sarcolemmal ATPases.

Authors:  M Karmazyn; B S Tuana; N S Dhalla
Journal:  Can J Physiol Pharmacol       Date:  1981-11       Impact factor: 2.273

4.  Effect of prostacyclin on the severity of ischaemic injury in rabbit hearts subjected to coronary ligation.

Authors:  A Edlund; K Sahlin; A Wennmalm
Journal:  J Mol Cell Cardiol       Date:  1986-10       Impact factor: 5.000

5.  Prostacyclin protects ischemic reperfused myocardium in the dog by inhibition of neutrophil activation.

Authors:  P J Simpson; S E Mitsos; A Ventura; K P Gallagher; J C Fantone; G D Abrams; M A Schork; B R Lucchesi
Journal:  Am Heart J       Date:  1987-01       Impact factor: 4.749

6.  Effects of prostacyclin on contractile properties of isolated mammalian cardiac muscle.

Authors:  M M Couttenye; N M De Clerck; A G Herman; D L Brutsaert
Journal:  J Cardiovasc Pharmacol       Date:  1985 Sep-Oct       Impact factor: 3.105

7.  Prostanoids can modify response to electrical stimulus and 45Ca2+ exchange in isolated myocardial muscle cells.

Authors:  U N Das; A M Lee; G J Barritt
Journal:  Prostaglandins Leukot Med       Date:  1983-11

8.  Positive inotropic effect of a stable analogue of PGI2 and of PGI2 on isolated guinea pig atria. Mechanism of action.

Authors:  G Fassina; F Tessari; P Dorigo
Journal:  Pharmacol Res Commun       Date:  1983-09

9.  Cyclic AMP-dependent and -independent effects of prostaglandins on the contraction-relaxation cycle of spontaneously beating isolated rat atria.

Authors:  T Metsä-Ketelä
Journal:  Acta Physiol Scand       Date:  1981-08

10.  The cardiac effects of prostaglandins and their modification by the prostaglandin antagonist N-0164.

Authors:  G Allan; R Levi
Journal:  J Pharmacol Exp Ther       Date:  1980-07       Impact factor: 4.030
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  7 in total

1.  Is prostacyclin an inodilator?

Authors:  Sven-Erik Ricksten
Journal:  Intensive Care Med       Date:  2003-08-02       Impact factor: 17.440

Review 2.  The use, and misuse, of exogenous endothelial-derived vasodilators in acute respiratory failure.

Authors:  A T Dinh-Xuan; F Brunet; J F Dhainaut
Journal:  Intensive Care Med       Date:  1997-11       Impact factor: 17.440

3.  Epoprostenol treatment of acute pulmonary hypertension is associated with a paradoxical decrease in right ventricular contractility.

Authors:  Steffen Rex; Carlo Missant; Patrick Segers; Rolf Rossaint; Patrick F Wouters
Journal:  Intensive Care Med       Date:  2007-08-21       Impact factor: 17.440

4.  Iloprost improves ventricular function in the hypertrophic and functionally impaired right heart by direct stimulation.

Authors:  Sarah Holmboe; Asger Andersen; Mads D Vildbrad; Jan M Nielsen; Steffen Ringgaard; Jens E Nielsen-Kudsk
Journal:  Pulm Circ       Date:  2013-12       Impact factor: 3.017

5.  The prostaglandins epoprostenol and iloprost increase left ventricular contractility in vivo.

Authors:  Hille Kisch-Wedel; Gregor Kemming; Franz Meisner; Michael Flondor; Wolfgang M Kuebler; Sebastian Bruhn; Carolina Koehler; Bernhard Zwissler
Journal:  Intensive Care Med       Date:  2003-08-08       Impact factor: 17.440

6.  Prostacyclins have no direct inotropic effect on isolated atrial strips from the normal and pressure-overloaded human right heart.

Authors:  Sarah Holmboe; Asger Andersen; Rebekka V Jensen; Hans Henrik Kimose; Lars B Ilkjær; Lei Shen; Lucie H Clapp; Jens Erik Nielsen-Kudsk
Journal:  Pulm Circ       Date:  2017-05-30       Impact factor: 3.017

7.  Effects of inhaled iloprost on right ventricular contractility, right ventriculo-vascular coupling and ventricular interdependence: a randomized placebo-controlled trial in an experimental model of acute pulmonary hypertension.

Authors:  Steffen Rex; Carlo Missant; Piet Claus; Wolfgang Buhre; Patrick F Wouters
Journal:  Crit Care       Date:  2008-09-10       Impact factor: 9.097
  7 in total

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