UNLABELLED: Trimethoprim-sulphamethoxazole (TMP-SMZ) is considered a safe drug for treatment of infectious bacterial diseases in children. Side-effects are rare and generally take the form of a hypersensitivity reaction to the sulphamethoxazole component of the drug. Hepatic injury usually presents as a transient elevation of liver enzymes, which is of little clinical relevance. Fulminant liver failure due to TMP-SMZ has been reported in only six adults and never in children. We here report a 5-year-old girl who developed fulminant liver failure 3 weeks after her third exposure to TMP-SMZ. After a biphasic clinical course she underwent successful liver transplantation. CONCLUSION: Trimethoprim-Sulphamethoxazole may cause fulminant liver failure in children. The disease can run a biphasic clinical course and liver transplantation must be considered as the therapeutic option for these patients.
UNLABELLED: Trimethoprim-sulphamethoxazole (TMP-SMZ) is considered a safe drug for treatment of infectious bacterial diseases in children. Side-effects are rare and generally take the form of a hypersensitivity reaction to the sulphamethoxazole component of the drug. Hepatic injury usually presents as a transient elevation of liver enzymes, which is of little clinical relevance. Fulminant liver failure due to TMP-SMZ has been reported in only six adults and never in children. We here report a 5-year-old girl who developed fulminant liver failure 3 weeks after her third exposure to TMP-SMZ. After a biphasic clinical course she underwent successful liver transplantation. CONCLUSION:Trimethoprim-Sulphamethoxazole may cause fulminant liver failure in children. The disease can run a biphasic clinical course and liver transplantation must be considered as the therapeutic option for these patients.
Authors: D Devictor; L Desplanques; D Debray; Y Ozier; A M Dubousset; J Valayer; D Houssin; O Bernard; G Huault Journal: Hepatology Date: 1992-11 Impact factor: 17.425
Authors: M Burdelski; M Oellerich; J Düwel; H Raith; M Scheruhn; B Ringe; B Rodeck; A Latta; R Pichlmayr; J Brodehl Journal: Eur J Pediatr Date: 1992 Impact factor: 3.183
Authors: J F Samson; P G Barth; J I de Vries; F H Menko; W Ruitenbeek; B A van Oost; C Jakobs Journal: Eur J Pediatr Date: 1994-07 Impact factor: 3.183
Authors: M R Mazziotta; E Ricci; E Bertini; C Dionisi Vici; S Servidei; A B Burlina; G Sabetta; A Bartuli; G Manfredi; G Silvestri Journal: J Pediatr Date: 1992-12 Impact factor: 4.406