Literature DB >> 7556071

The Polycomb-group gene, extra sex combs, encodes a nuclear member of the WD-40 repeat family.

T Gutjahr1, E Frei, C Spicer, S Baumgartner, R A White, M Noll.   

Abstract

We have delimited the extra sex combs (esc) gene to < 4 kb that include a single transcript and are able to rescue both the maternal and zygotic esc phenotypes. Several mutations have been identified within the esc transcript. In agreement with earlier genetic studies, esc is expressed maternally and its product is most abundant during the early embryonic stages. It encodes a protein of the WD-40 repeat family, which localizes predominantly to the nucleus. During germ band extension, it is expressed in a stereotypic pattern of neuroblasts. We propose a model in which Esc is recruited by gap proteins both to act as a corepressor that competes with the TAFII80 coactivator to block transcription and also to mediate the transition to permanent repression by Polycomb-group proteins.

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Year:  1995        PMID： 7556071      PMCID： PMC394514          DOI： 10.1002/j.1460-2075.1995.tb00104.x

Source DB:  PubMed          Journal:  EMBO J        ISSN： 0261-4189            Impact factor:   11.598


  82 in total

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  27 in total

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Review 3.  Genomic imprinting and endosperm development in flowering plants.

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Journal:  Mol Cell Biol       Date:  1997-11       Impact factor: 4.272

5.  Evolutionary conservation and predicted structure of the Drosophila extra sex combs repressor protein.

Authors:  J Ng; R Li; K Morgan; J Simon
Journal:  Mol Cell Biol       Date:  1997-11       Impact factor: 4.272

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Authors:  Angela M Holmes; Kelly A Weedmark; Gregory B Gloor
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7.  Interaction of mouse polycomb-group (Pc-G) proteins Enx1 and Enx2 with Eed: indication for separate Pc-G complexes.

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8.  Characterization of interactions between the mammalian polycomb-group proteins Enx1/EZH2 and EED suggests the existence of different mammalian polycomb-group protein complexes.

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9.  Molecular and functional mapping of EED motifs required for PRC2-dependent histone methylation.

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10.  Polycomb silencing of the Drosophila 4E-BP gene regulates imaginal disc cell growth.

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Journal:  Dev Biol       Date:  2013-03-20       Impact factor: 3.582
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