Literature DB >> 7554463

Immunodeficiency in IL-2-knockout mice.

I Horak1.   

Abstract

Interleukin-2-deficient mice (IL-2-/-) generated by targeted mutagenesis proved to be an excellent system to study the function of this lymphokine in the context of whole immune system. In addition, they provide an animal model of a primary immunodeficiency caused by a single-gene defect. Our results indicate that the essential degect in IL-2-/- mice is the lack of a negative regulatory function, which leads to breakdown of self tolerance. The development of autoimmune diseases in IL-2-deficient mice stresses the link between autoimmunity and primary immunodeficiencies.

Entities:  

Mesh：

Substances：

Year:  1995        PMID： 7554463     DOI： 10.1016/s0090-1229(95)90126-4

Source DB:  PubMed          Journal:  Clin Immunol Immunopathol        ISSN： 0090-1229


  15 in total

1.  IL-2 gene C/T polymorphism is associated with prostate cancer.

Authors:  Hsi-Chin Wu; Chao-Hsiang Chang; Lei Wan; Chao-I Wu; Fuu-Jen Tsai; Wen-Chi Chen
Journal:  J Clin Lab Anal       Date:  2006       Impact factor: 2.352

2.  Loss of cholinergic phenotype in septohippocampal projection neurons: relation to brain versus peripheral IL-2 deficiency.

Authors:  Danielle M Meola; Zhi Huang; Michael King; John M Petitto
Journal:  Neurosci Lett       Date:  2013-02-13       Impact factor: 3.046

3.  Lipoteichoic acid inhibits interleukin-2 (IL-2) function by direct binding to IL-2.

Authors:  L M Plitnick; R A Jordan; J A Banas; D M Jelley-Gibbs; M C Walsh; M T Preissler; E J Gosselin
Journal:  Clin Diagn Lab Immunol       Date:  2001-09

Review 4.  Immunological self/nonself discrimination: integration of self vs nonself during cognate T cell interactions with antigen-presenting cells.

Authors:  M D Mannie
Journal:  Immunol Res       Date:  1999       Impact factor: 2.829

Review 5.  Autoimmunity, immunodeficiency and mucosal infections: chronic intestinal inflammation as a sensitive indicator of immunoregulatory defects in response to normal luminal microflora.

Authors:  H Tlaskalová-Hogenová; R Stĕpánková; L Tucková; M A Farré; D P Funda; E F Verdú; J Sinkora; T Hudcovic; Z Reháková; B Cukrowska; H Kozáková; L Prokesová
Journal:  Folia Microbiol (Praha)       Date:  1998       Impact factor: 2.099

6.  Biphasic regulation of Il2 transcription in CD4+ T cells: roles for TNF-alpha receptor signaling and chromatin structure.

Authors:  Susan C McKarns; Ronald H Schwartz
Journal:  J Immunol       Date:  2008-07-15       Impact factor: 5.422

7.  The role of microRNA-31 and microRNA-21 as regulatory biomarkers in the activation of T lymphocytes of Egyptian lupus patients.

Authors:  Khalda Sayed Amr; Faten S Bayoumi; Fatema T Elgengehy; Sanaa O Abdallah; Hanan H Ahmed; Eman Eissa
Journal:  Rheumatol Int       Date:  2016-08-10       Impact factor: 2.631

8.  Effects of Brain-Derived IL-2 Deficiency and the Development of Autoimmunity on Spatial Learning and Fear Conditioning.

Authors:  John M Petitto; Jesse D Cushman; Zhi Huang
Journal:  J Neurol Disord       Date:  2015

9.  CD8+ T Cell Fate and Function Influenced by Antigen-Specific Virus-Like Nanoparticles Co-Expressing Membrane Tethered IL-2.

Authors:  Daniela Wojta-Stremayr; Alina Neunkirchner; Bharani Srinivasan; Doris Trapin; Klaus G Schmetterer; Winfried F Pickl
Journal:  PLoS One       Date:  2015-05-06       Impact factor: 3.240

10.  A population dynamics analysis of the interaction between adaptive regulatory T cells and antigen presenting cells.

Authors:  David Fouchet; Roland Regoes
Journal:  PLoS One       Date:  2008-05-28       Impact factor: 3.240
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.