Literature DB >> 7553983

Search for naturally occurring substances to prevent the complications of diabetes. II. Inhibitory effect of coumarin and flavonoid derivatives on bovine lens aldose reductase and rabbit platelet aggregation.

Y Okada1, N Miyauchi, K Suzuki, T Kobayashi, C Tsutsui, K Mayuzumi, S Nishibe, T Okuyama.   

Abstract

An EtOAc extract of Artemisiae Capillari Spica inhibited both bovine lens aldose reductase (bovine-LAR) and rabbit platelet aggregation. Two simple coumarins, scoparone (1) and scopoletin (2), and three flavonoids, capillarisin (21), cirsimaritin (22) and rhamnocitrin (23), were isolated from this extract. Scoparone (1) and scopoletin (2) exhibit a potent inhibitory effect on rabbit platelet aggregation induced by four types of agent, ADP, PAF, sodium arachidonate and/or collagen. Capillarisin (21) exhibits a potent inhibitory effect on bovine-LAR. In addition, thirteen simple coumarins, five coumarin glycosides and two flavonoids were tested for their inhibitory effect against bovine-LAR and rabbit platelet aggregation.

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Year:  1995        PMID： 7553983     DOI： 10.1248/cpb.43.1385

Source DB:  PubMed          Journal:  Chem Pharm Bull (Tokyo)        ISSN： 0009-2363            Impact factor:   1.645


  13 in total

1.  UDP-Glucuronosyltransferases 1A6 and 1A9 are the Major Isozymes Responsible for the 7-O-Glucuronidation of Esculetin and 4-Methylesculetin in Human Liver Microsomes.

Authors:  Lijun Zhu; Linlin Lu; Shan Zeng; Feifei Luo; Peimin Dai; Peng Wu; Ying Wang; Liang Liu; Ming Hu; Zhongqiu Liu
Journal:  Drug Metab Dispos       Date:  2015-04-08       Impact factor: 3.922

2.  Esculetin has therapeutic potential via the proapoptotic signaling pathway in A253 human submandibular salivary gland tumor cells.

Authors:  Su-Bin Park; Woo Kwon Jung; Hyung Rae Kim; Hwa-Young Yu; Yong Hwan Kim; Junghyun Kim
Journal:  Exp Ther Med       Date:  2022-06-22       Impact factor: 2.751

3.  The effect of capillarisin on glycochenodeoxycholic acid-induced apoptosis and heme oxygenase-1 in rat primary hepatocytes.

Authors:  Tzung-Yan Lee; Fang-Yu Chen; Hen-Hong Chang; Han-Chieh Lin
Journal:  Mol Cell Biochem       Date:  2009-01-09       Impact factor: 3.396

4.  Selective methylation of kaempferol via benzylation and deacetylation of kaempferol acetates.

Authors:  Qinggang Mei; Chun Wang; Weicheng Yuan; Guolin Zhang
Journal:  Beilstein J Org Chem       Date:  2015-02-25       Impact factor: 2.883

Review 5.  Evaluation of chemical constituents and important mechanism of pharmacological biology in dendrobium plants.

Authors:  Yau Lam; Tzi Bun Ng; Ren Ming Yao; Jun Shi; Kai Xu; Stephen Cho Wing Sze; Kalin Yanbo Zhang
Journal:  Evid Based Complement Alternat Med       Date:  2015-04-06       Impact factor: 2.629

6.  Esculetin, a Coumarin Derivative, Exhibits Anti-proliferative and Pro-apoptotic Activity in G361 Human Malignant Melanoma.

Authors:  Young-Joo Jeon; Jeong-Yun Jang; Jung-Hyun Shim; Pyung Keun Myung; Jung-Il Chae
Journal:  J Cancer Prev       Date:  2015-06

Review 7.  Recent Studies and Progression of Yin Chen Hao ( Yīn Chén Hāo), a Long-term Used Traditional Chinese Medicine.

Authors:  Hsin-Yi Hung; Sheng-Chu Kuo
Journal:  J Tradit Complement Med       Date:  2013-01

8.  Analysis and distribution of esculetin in plasma and tissues of rats after oral administration.

Authors:  Ji-Sun Kim; Tae-Youl Ha; Jiyun Ahn; Suna Kim
Journal:  Prev Nutr Food Sci       Date:  2014-12-31

9.  Quality parameters, fatty acid profiling and estimation of umbelliferone in grahaṇimihira tailam: An ayurvedic oil preparation.

Authors:  M Deepak; Prakash U Kumar; B Nitha; Indira Balachandran; A B Rema Shree
Journal:  Anc Sci Life       Date:  2013-07

10.  Bioactive metabolites from Spilanthes acmella Murr.

Authors:  Supaluk Prachayasittikul; Saowapa Suphapong; Apilak Worachartcheewan; Ratana Lawung; Somsak Ruchirawat; Virapong Prachayasittikul
Journal:  Molecules       Date:  2009-02-19       Impact factor: 4.411
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