Literature DB >> 7553965

Synthesis and pharmacological evaluation of 1,2,3,4-tetrahydro-beta-carboline derivatives.

Y Kawashima1, A Horiguchi, M Taguchi, Y Tuyuki, Y Karasawa, H Araki, K Hatayama.   

Abstract

A series of 1,2,3,4-tetrahydro-beta-carbolines has been synthesized and evaluated for cerebral protecting effects against lipid peroxidation and potassium cyanide intoxication in mice. Most of the compounds synthesized had potent effects against lipid peroxidation. Among them, 1-(3,5-dimethoxyphenyl)-2-propyl-1,2,3,4-tetrahydro-beta-carboline (22) was found to have a combination of potent effects against both lipid peroxidation and potassium cyanide intoxication. Structure-activity relationships are discussed.

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Year:  1995        PMID： 7553965     DOI： 10.1248/cpb.43.783

Source DB:  PubMed          Journal:  Chem Pharm Bull (Tokyo)        ISSN： 0009-2363            Impact factor:   1.645


  4 in total

1.  Role of pinoline and melatonin in stabilizing hepatic microsomal membranes against oxidative stress.

Authors:  J J García; R J Reiter; J Pié; G G Ortiz; J Cabrera; R M Sáinz; D Acuña-Castroviejo
Journal:  J Bioenerg Biomembr       Date:  1999-12       Impact factor: 2.945

2.  Synthesis of 1-substituted carbazolyl-1,2,3,4-tetrahydro- and carbazolyl-3,4-dihydro-β-carboline analogs as potential antitumor agents.

Authors:  Ya-Ching Shen; Yao-To Chang; Chun-Ling Lin; Chia-Ching Liaw; Yao Haur Kuo; Lan-Chun Tu; Sheau Farn Yeh; Ji-Wang Chern
Journal:  Mar Drugs       Date:  2011-02-10       Impact factor: 6.085

3.  Macrophage Migration Inhibitory Factor Acts as the Potential Target of a Newly Synthesized Compound, 1-(9'-methyl-3'-carbazole)-3, 4-dihydro-β-carboline.

Authors:  Pin-Hao Ko; Ya-Ching Shen; Kaliyappan Murugan; Chiung-Wei Huang; Govindan Sivakumar; Pinki Pal; Chia-Ching Liao; Kai-Shin Luo; Eric Y Chuang; Mong-Hsun Tsai; Liang-Chuan Lai
Journal:  Sci Rep       Date:  2019-02-14       Impact factor: 4.379

Review 4.  Interaction of Neuromelanin with Xenobiotics and Consequences for Neurodegeneration; Promising Experimental Models.

Authors:  Andrea Capucciati; Fabio A Zucca; Enrico Monzani; Luigi Zecca; Luigi Casella; Tim Hofer
Journal:  Antioxidants (Basel)       Date:  2021-05-21
  4 in total

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