Literature DB >> 7552743

Proposed structure of the A domains of factor VIII by homology modelling.

Y Pan, T DeFay, J Gitschier, F E Cohen.   

Abstract

We have predicted a structure for the three A domains of blood coagulation factor VIII by virtue of their homology to blue copper-binding proteins. This structure, consisting of six beta-barrels, is arranged in a triangular configuration with a single type II copper-binding site linking the A1 and A3 domains.

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Year:  1995        PMID: 7552743     DOI: 10.1038/nsb0995-740

Source DB:  PubMed          Journal:  Nat Struct Biol        ISSN: 1072-8368


  5 in total

1.  Structural comparison of cupredoxin domains: domain recycling to construct proteins with novel functions.

Authors:  M E Murphy; P F Lindley; E T Adman
Journal:  Protein Sci       Date:  1997-04       Impact factor: 6.725

2.  Binding sites for blood coagulation factor Xa and protein S involving residues 493-506 in factor Va.

Authors:  M J Heeb; Y Kojima; T M Hackeng; J H Griffin
Journal:  Protein Sci       Date:  1996-09       Impact factor: 6.725

3.  Nonenzymatic anticoagulant activity of the mutant serine protease Ser360Ala-activated protein C mediated by factor Va.

Authors:  A J Gale; X Sun; M J Heeb; J H Griffin
Journal:  Protein Sci       Date:  1997-01       Impact factor: 6.725

4.  A theoretical model for the Gla-TSR-EGF-1 region of the anticoagulant cofactor protein S: from biostructural pathology to species-specific cofactor activity.

Authors:  B O Villoutreix; O Teleman; B Dahlbäck
Journal:  J Comput Aided Mol Des       Date:  1997-05       Impact factor: 3.686

5.  Structural investigation of the A domains of human blood coagulation factor V by molecular modeling.

Authors:  B O Villoutreix; B Dahlbäck
Journal:  Protein Sci       Date:  1998-06       Impact factor: 6.725

  5 in total

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