W H Eaglstein1, M Iriondo, K Laszlo. 1. Department of Dermatology, University of Miami School of Medicine, FL 33101, USA.
Abstract
BACKGROUND: Bioengineered skin substitutes offer tissue replacement without requiring a donor site and might produce better healing. OBJECTIVE: To evaluate the recipient's response to grafting a bioengineered skin equivalent onto acute surgical wounds. METHODS: Graftskin, which is made of: 1) a bovine collagen matrix containing human fibroblasts, and 2) an overlying sheet of stratified human epithelium, was grafted onto the excision sites of 15 patients. RESULTS: Blood and cell studies for toxicity were negative. Graftskin proved easy to handle, and a typical clinical appearance of the skin substitute during "take" was detected. Compared with expectations improved healing occurred. Twelve of 15 patients had initial clinical takes. CONCLUSION: Graftskin was not clinically rejected and was not toxic. It often appeared to take and produced better than expected healing.
BACKGROUND: Bioengineered skin substitutes offer tissue replacement without requiring a donor site and might produce better healing. OBJECTIVE: To evaluate the recipient's response to grafting a bioengineered skin equivalent onto acute surgical wounds. METHODS: Graftskin, which is made of: 1) a bovine collagen matrix containing human fibroblasts, and 2) an overlying sheet of stratified human epithelium, was grafted onto the excision sites of 15 patients. RESULTS: Blood and cell studies for toxicity were negative. Graftskin proved easy to handle, and a typical clinical appearance of the skin substitute during "take" was detected. Compared with expectations improved healing occurred. Twelve of 15 patients had initial clinical takes. CONCLUSION: Graftskin was not clinically rejected and was not toxic. It often appeared to take and produced better than expected healing.
Authors: Michael J Schurr; Kevin N Foster; Mary A Lokuta; Cathy A Rasmussen; Christina L Thomas-Virnig; Lee D Faucher; Daniel M Caruso; B Lynn Allen-Hoffmann Journal: Adv Wound Care (New Rochelle) Date: 2012-04 Impact factor: 4.730
Authors: A Srivastava; E Z DeSagun; L J Jennings; S Sethi; A Phuangsab; M Hanumadass; H M Reyes; R J Walter Journal: Ann Surg Date: 2001-03 Impact factor: 12.969