SETTING:Child welfare division of a university-based department of pediatrics in Turkey. OBJECTIVE: To determine specific IgM and IgG response after BCG vaccination. DESIGN: Prospective, randomized trial. METHODS: Serum samples of 66 infants were taken before and at 2, 4, 6 and 15 months after vaccination. 35 infants were vaccinated at the first month and 31 at the second month after delivery. An ELISA assay was performed using PPD antigen. RESULTS:IgM antibodies increased significantly (P < 0.05) during the post-vaccination period. On the other hand IgG antibodies decreased in the second month after vaccination. At the fourth month the IgG level began to rise continuously (P < 0.01). The infants who were vaccinated at the second month showed a higher IgM response at the second and fourth month than those vaccinated in the first month (P < 0.05), but the difference was not visible thereafter (P > 0.05). 52 infants (78%) were tuberculin positive 8 weeks after vaccination. CONCLUSION: Anti-PPD IgM and IgG levels rise progressively in BCG-vaccinated infants.
RCT Entities:
SETTING:Child welfare division of a university-based department of pediatrics in Turkey. OBJECTIVE: To determine specific IgM and IgG response after BCG vaccination. DESIGN: Prospective, randomized trial. METHODS: Serum samples of 66 infants were taken before and at 2, 4, 6 and 15 months after vaccination. 35 infants were vaccinated at the first month and 31 at the second month after delivery. An ELISA assay was performed using PPD antigen. RESULTS: IgM antibodies increased significantly (P < 0.05) during the post-vaccination period. On the other hand IgG antibodies decreased in the second month after vaccination. At the fourth month the IgG level began to rise continuously (P < 0.01). The infants who were vaccinated at the second month showed a higher IgM response at the second and fourth month than those vaccinated in the first month (P < 0.05), but the difference was not visible thereafter (P > 0.05). 52 infants (78%) were tuberculin positive 8 weeks after vaccination. CONCLUSION: Anti-PPD IgM and IgG levels rise progressively in BCG-vaccinated infants.
Authors: Christiane M Schmidt; Kathryn L Lovero; Fabiana R Carvalho; Daniele C M Dos Santos; Ana Cláudia M W Barros; Ana Paula Quintanilha; Ana Paula Barbosa; Marcos V S Pone; Sheila M Pone; Julienne Martins Araujo; Camila de Paula Martins; Solange G D Macedo; Ana Lúcia Miceli; Maria Luíza Vieira; Selma M A Sias; Adriano Queiroz; Luis Guillermo Coca Velarde; Afranio L Kritski; Andrea A Silva; Clemax C Sant'Anna; Lee W Riley; Claudete A Araújo Cardoso Journal: Tuberculosis (Edinb) Date: 2019-12-05 Impact factor: 3.131
Authors: Helen A Fletcher; Margaret A Snowden; Bernard Landry; Wasima Rida; Iman Satti; Stephanie A Harris; Magali Matsumiya; Rachel Tanner; Matthew K O'Shea; Veerabadran Dheenadhayalan; Leah Bogardus; Lisa Stockdale; Leanne Marsay; Agnieszka Chomka; Rachel Harrington-Kandt; Zita-Rose Manjaly-Thomas; Vivek Naranbhai; Elena Stylianou; Fatoumatta Darboe; Adam Penn-Nicholson; Elisa Nemes; Mark Hatherill; Gregory Hussey; Hassan Mahomed; Michele Tameris; J Bruce McClain; Thomas G Evans; Willem A Hanekom; Thomas J Scriba; Helen McShane Journal: Nat Commun Date: 2016-04-12 Impact factor: 14.919