Literature DB >> 7548840

The bcl-2 gene family.

R W Craig1.   

Abstract

Viability is a fundamental determinant of all cellular functions, and regulation of cell viability is important in shaping tissue differentiation and organism development. The genes in the bcl-2 family can profoundly influence cell viability. In addition to bcl-2, cellular genes in this family include bcl-x, bax, mcl-1, and A1 (from vertebrates), as well as ced9 (from Caenorhabditis elegans). Different members of the family exhibit a spectrum of activity, ranging from survival-enhancement of death-enhancement. Thus, the combinatorial effects of various bcl-2 family members may allow a fine level of control over the important function of cell viability. In addition, alterations in these genes may cause aberations in cell death and thus contribute to cancer.

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Year:  1995        PMID： 7548840     DOI： 10.1006/scbi.1995.0005

Source DB:  PubMed          Journal:  Semin Cancer Biol        ISSN： 1044-579X            Impact factor:   15.707


  24 in total

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Authors:  L C Spender; E J Cannell; M Hollyoake; B Wensing; J M Gawn; M Brimmell; G Packham; P J Farrell
Journal:  J Virol       Date:  1999-06       Impact factor: 5.103

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Journal:  Pharm World Sci       Date:  1997-06

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Journal:  Urol Res       Date:  1996

4.  ABT-263 induces G1/G0-phase arrest, apoptosis and autophagy in human esophageal cancer cells in vitro.

Authors:  Qing-Huan Lin; Fu-Chang Que; Chun-Ping Gu; De-Sheng Zhong; Dan Zhou; Yi Kong; Le Yu; Shu-Wen Liu
Journal:  Acta Pharmacol Sin       Date:  2017-07-10       Impact factor: 6.150

Review 5.  Antipsychotic drugs: comparison in animal models of efficacy, neurotransmitter regulation, and neuroprotection.

Authors:  Jeffrey A Lieberman; Frank P Bymaster; Herbert Y Meltzer; Ariel Y Deutch; Gary E Duncan; Christine E Marx; June R Aprille; Donard S Dwyer; Xin-Min Li; Sahebarao P Mahadik; Ronald S Duman; Joseph H Porter; Josephine S Modica-Napolitano; Samuel S Newton; John G Csernansky
Journal:  Pharmacol Rev       Date:  2008-09       Impact factor: 25.468

6.  Electro-acupuncture reduces neuronal apoptosis linked to Bax and Bcl-2 expression in the spinal cords of cats subjected to partial dorsal root ganglionectomy.

Authors:  Wei Zhao; Qi Zhao; Jia Liu; Xin-Yun Xu; Wei-Wei Sun; Xue Zhou; Su Liu; Ting-Hua Wang
Journal:  Neurochem Res       Date:  2008-04-10       Impact factor: 3.996

7.  Cytoplasmic sequestration of p53 in cytomegalovirus-infected human endothelial cells.

Authors:  A Kovacs; M L Weber; L J Burns; H S Jacob; G M Vercellotti
Journal:  Am J Pathol       Date:  1996-11       Impact factor: 4.307

Review 8.  [Significance of apoptotic processes in radiotherapy. I].

Authors:  M Abend; D van Beuningen
Journal:  Strahlenther Onkol       Date:  1998-03       Impact factor: 3.621

9.  The intrinsic radioresistance of glioblastoma-derived cell lines is associated with a failure of p53 to induce p21(BAX) expression.

Authors:  H K Shu; M M Kim; P Chen; F Furman; C M Julin; M A Israel
Journal:  Proc Natl Acad Sci U S A       Date:  1998-11-24       Impact factor: 11.205

10.  Differential cell killing by lymphomagenic murine leukemia viruses occurs independently of p53 activation and mitochondrial damage.

Authors:  Suparna Nanua; Fayth K Yoshimura
Journal:  J Virol       Date:  2004-05       Impact factor: 5.103
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