| Literature DB >> 7548219 |
H Watanabe1, K Fukuchi, Y Takagi, S Tomoyasu, N Tsuruoka, K Gomi.
Abstract
We have screened for mutations in the Cip1/Waf1 gene using Southern blot analysis and the polymerase chain reaction single-strand conformation polymorphism (PCR-SSCP) method in diverse human tumors. Seven of 102 (7%) human tumor samples were identified to have point mutations within the coding region of the Cip1/Waf1 gene. Two of the seven mutated cases showed gene rearrangements. These results suggest that the frequency of genetic alterations in the Cip1/Waf1 gene is relatively low in comparison with several known tumor suppressor genes.Entities:
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Year: 1995 PMID： 7548219 DOI： 10.1016/0167-4781(95)00110-3
Source DB: PubMed Journal: Biochim Biophys Acta ISSN： 0006-3002