OBJECTIVE: To establish the time of onset of dilated cardiomyopathy (DCM) by review of annual chest x rays, which are obligatory in Hungary. DESIGN: A retrospective survey of chest x rays of a cohort of confirmed cases of DCM, to assess time of onset of cardiomegaly. Clinical course was compared by follow up over a mean of six years from the time of diagnosis. SUBJECTS: 240 patients with DCM (31 familial, 209 non-familial). Diagnosis was made by echocardiography in all cases and confirmed by coronary angiography and heart biopsy in some cases. MAIN RESULTS: At diagnosis, the mean age of the patients was 31.8 years in the familial group and 39.6 years in the non-familial group (P < 0.05). The time between the onset of cardiomegaly (cardiothoracic ratio > 0.45) and clinical diagnosis was 8.0 and 10.1 years respectively (P < 0.05). The six year survival was 6% in the familial group and 23% in the non-familial group (P < 0.05). CONCLUSIONS: The familial form of DCM is the more malignant form: it occurs at an earlier age and progresses more rapidly than non-familial DCM.
OBJECTIVE: To establish the time of onset of dilated cardiomyopathy (DCM) by review of annual chest x rays, which are obligatory in Hungary. DESIGN: A retrospective survey of chest x rays of a cohort of confirmed cases of DCM, to assess time of onset of cardiomegaly. Clinical course was compared by follow up over a mean of six years from the time of diagnosis. SUBJECTS: 240 patients with DCM (31 familial, 209 non-familial). Diagnosis was made by echocardiography in all cases and confirmed by coronary angiography and heart biopsy in some cases. MAIN RESULTS: At diagnosis, the mean age of the patients was 31.8 years in the familial group and 39.6 years in the non-familial group (P < 0.05). The time between the onset of cardiomegaly (cardiothoracic ratio > 0.45) and clinical diagnosis was 8.0 and 10.1 years respectively (P < 0.05). The six year survival was 6% in the familial group and 23% in the non-familial group (P < 0.05). CONCLUSIONS: The familial form of DCM is the more malignant form: it occurs at an earlier age and progresses more rapidly than non-familial DCM.
Authors: V V Michels; P P Moll; F A Miller; A J Tajik; J S Chu; D J Driscoll; J C Burnett; R J Rodeheffer; J H Chesebro; H D Tazelaar Journal: N Engl J Med Date: 1992-01-09 Impact factor: 91.245
Authors: E Zachara; A L Caforio; G P Carboni; A Pellegrini; A Pompili; G Del Porto; A Sciarra; C Bosman; R Boldrini; P L Prati Journal: Br Heart J Date: 1993-02
Authors: Folkert W Asselbergs; Arjan Sammani; Perry Elliott; Juan R Gimeno; Luigi Tavazzi; Michael Tendera; Juan Pablo Kaski; Aldo P Maggioni; Pawel P Rubis; Ruxandra Jurcut; Tiina Heliö; Leonardo Calò; Gianfranco Sinagra; Marija Zdravkovic; Iacopo Olivotto; Aušra Kavoliūnienė; Cécile Laroche; Alida L P Caforio; Philippe Charron Journal: ESC Heart Fail Date: 2020-11-11