| Literature DB >> 7546547 |
G L Silva1, H Chai, M P Gupta, N R Farnsworth, G A Cordell, J M Pezzuto, C W Beecher, A D Kinghorn.
Abstract
Bioactivity-guided fractionation of the leaves of Selaginella willdenowii afforded three known biflavones, 4',7"-di-O-methylamentoflavone, isocryptomerin and 7"-O-methylrobustaflavone, that were significantly cytotoxic against a panel of human cancer cell lines. Non-cytotoxic isolates were also obtained, namely, amentoflavone, bilobetin, robustaflavone and 2",3"-dihydroisocryptomerin, a new dihydrobiflavone. The structure for the new biflavonoid was unambiguously assigned by a combination of spectroscopic methods.Entities:
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Year: 1995 PMID： 7546547 DOI： 10.1016/0031-9422(95)00212-p
Source DB: PubMed Journal: Phytochemistry ISSN： 0031-9422 Impact factor: 4.072