Literature DB >> 7546206

The origin of CD4-CD8-TCR alpha beta+ thymocytes: a model based on T-cell receptor avidity.

R C Budd1, P F Mixter.   

Abstract

Ralph Budd and Philip Mixter present a hypothesis suggesting that CD4-CD8-TCR alpha beta+ cells arising in the normal thymus result from a high-avidity T-cell receptor (TCR) signal bordering on negative selection. In normal mice, this subset is likely to be gradually deleted but, in the absence of Fas, these cells persist in lpr mice. The model they describe makes several predictions regarding the nature of this unusual T-cell subset.

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Year:  1995        PMID： 7546206     DOI： 10.1016/0167-5699(95)80019-0

Source DB:  PubMed          Journal:  Immunol Today        ISSN： 0167-5699


  10 in total

Review 1.  T cell-mediated antigen presentation: a potential mechanism of infectious tolerance.

Authors:  M D Mannie
Journal:  Immunol Res       Date:  2001       Impact factor: 2.829

2.  Mechanism of human immunodeficiency virus type 1 localization in CD4-negative thymocytes: differentiation from a CD4-positive precursor allows productive infection.

Authors:  S G Kitchen; C H Uittenbogaart; J A Zack
Journal:  J Virol       Date:  1997-08       Impact factor: 5.103

Review 3.  Role of gonadal hormones in programming developmental changes in thymopoietic efficiency and sexual diergism in thymopoiesis.

Authors:  Gordana Leposavic; Milica Perisic; Ivan Pilipovic
Journal:  Immunol Res       Date:  2012-04       Impact factor: 2.829

4.  Thymocyte-thymic epithelial cell interaction leads to high-level replication of human immunodeficiency virus exclusively in mature CD4(+) CD8(-) CD3(+) thymocytes: a critical role for tumor necrosis factor and interleukin-7.

Authors:  L Chêne; M T Nugeyre; E Guillemard; N Moulian; F Barré-Sinoussi; N Israël
Journal:  J Virol       Date:  1999-09       Impact factor: 5.103

5.  Generation of NK1.1+ T cell antigen receptor alpha/beta+ thymocytes associated with intact thymic structure.

Authors:  K Nakagawa; K Iwabuchi; K Ogasawara; M Ato; M Kajiwara; H Nishihori; C Iwabuchi; H Ishikura; R A Good; K Onoé
Journal:  Proc Natl Acad Sci U S A       Date:  1997-03-18       Impact factor: 11.205

6.  Suppression of autoimmunity and organ pathology in lupus-prone mice upon inhibition of calcium/calmodulin-dependent protein kinase type IV.

Authors:  Kunihiro Ichinose; Yuang-Taung Juang; José C Crispín; Katalin Kis-Toth; George C Tsokos
Journal:  Arthritis Rheum       Date:  2011-02

7.  Intrathymic selection of NK1.1(+)alpha/beta T cell antigen receptor (TCR)+ cells in transgenic mice bearing TCR specific for chicken ovalbumin and restricted to I-Ad.

Authors:  C Iwabuchi; K Iwabuchi; K Nakagawa; T Takayanagi; H Nishihori; S Tone; K Ogasawara; R A Good; K Onoé
Journal:  Proc Natl Acad Sci U S A       Date:  1998-07-07       Impact factor: 11.205

8.  Premature expression of T cell receptor (TCR)alphabeta suppresses TCRgammadelta gene rearrangement but permits development of gammadelta lineage T cells.

Authors:  K Terrence; C P Pavlovich; E O Matechak; B J Fowlkes
Journal:  J Exp Med       Date:  2000-08-21       Impact factor: 14.307

9.  CD4-CD8- T cells control intracellular bacterial infections both in vitro and in vivo.

Authors:  Siobhán C Cowley; Elizabeth Hamilton; Jeffrey A Frelinger; Jie Su; James Forman; Karen L Elkins
Journal:  J Exp Med       Date:  2005-07-18       Impact factor: 14.307

10.  Liver damage preferentially results from CD8(+) T cells triggered by high affinity peptide antigens.

Authors:  J Q Russell; G J Morrissette; M Weidner; C Vyas; D Aleman-Hoey; R C Budd
Journal:  J Exp Med       Date:  1998-09-21       Impact factor: 14.307
  10 in total

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