Literature DB >> 7545515

Involvement of protein kinase C in the delayed cytoprotection following sublethal ischaemia in rabbit myocardium.

G F Baxter1, F M Goma, D M Yellon.   

Abstract

Rabbit hearts were preconditioned with four 5 min coronary artery occlusions 24 h before 30 min coronary occlusion with 120 min reperfusion. Preconditioning significantly reduced the percentage of myocardium infarcting within the risk zone from 49.1 +/- 4.3% to 31.8 +/- 3.5% (P < 0.05). When the protein kinase C (PKC) inhibitor, chelerythrine, was administered just before preconditioning, the delayed protection against infarction 24 h later was abolished. We conclude that the delayed cytoprotective response associated with ischaemic preconditioning of myocardium is likely to involve the early activation of one or more PKC subtypes.

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Year:  1995        PMID： 7545515      PMCID： PMC1908328          DOI： 10.1111/j.1476-5381.1995.tb15866.x

Source DB:  PubMed          Journal:  Br J Pharmacol        ISSN： 0007-1188            Impact factor:   8.739


  9 in total

Review 1.  Protein kinase C isoenzymes: divergence in signal transduction?

Authors:  H Hug; T F Sarre
Journal:  Biochem J       Date:  1993-04-15       Impact factor: 3.857

2.  Chelerythrine is a potent and specific inhibitor of protein kinase C.

Authors:  J M Herbert; J M Augereau; J Gleye; J P Maffrand
Journal:  Biochem Biophys Res Commun       Date:  1990-11-15       Impact factor: 3.575

3.  Delayed effects of sublethal ischemia on the acquisition of tolerance to ischemia.

Authors:  T Kuzuya; S Hoshida; N Yamashita; H Fuji; H Oe; M Hori; T Kamada; M Tada
Journal:  Circ Res       Date:  1993-06       Impact factor: 17.367

4.  Adenosine receptor involvement in a delayed phase of myocardial protection 24 hours after ischemic preconditioning.

Authors:  G F Baxter; M S Marber; V C Patel; D M Yellon
Journal:  Circulation       Date:  1994-12       Impact factor: 29.690

5.  Cardiac stress protein elevation 24 hours after brief ischemia or heat stress is associated with resistance to myocardial infarction.

Authors:  M S Marber; D S Latchman; J M Walker; D M Yellon
Journal:  Circulation       Date:  1993-09       Impact factor: 29.690

6.  Sublethal ischemia alters myocardial antioxidant activity in canine heart.

Authors:  S Hoshida; T Kuzuya; H Fuji; N Yamashita; H Oe; M Hori; K Suzuki; N Taniguchi; M Tada
Journal:  Am J Physiol       Date:  1993-01

7.  Induction of manganese superoxide dismutase in rat cardiac myocytes increases tolerance to hypoxia 24 hours after preconditioning.

Authors:  N Yamashita; M Nishida; S Hoshida; T Kuzuya; M Hori; N Taniguchi; T Kamada; M Tada
Journal:  J Clin Invest       Date:  1994-12       Impact factor: 14.808

8.  Prevention by dexamethasone of the marked antiarrhythmic effects of preconditioning induced 20 h after rapid cardiac pacing.

Authors:  A Vegh; J G Papp; J R Parratt
Journal:  Br J Pharmacol       Date:  1994-12       Impact factor: 8.739

9.  Adenosine acts as an endogenous activator of the cellular antioxidant defense system.

Authors:  S B Maggirwar; D N Dhanraj; S M Somani; V Ramkumar
Journal:  Biochem Biophys Res Commun       Date:  1994-06-15       Impact factor: 3.575
  9 in total
  21 in total

Review 1.  Therapeutic potential of ischaemic preconditioning.

Authors:  R J Edwards; A T Saurin; R D Rakhit; M S Marber
Journal:  Br J Clin Pharmacol       Date:  2000-08       Impact factor: 4.335

Review 2.  Organ preconditioning: the past, current status, and related lung studies.

Authors:  Shi-ping Luh; Pan-chyr Yang
Journal:  J Zhejiang Univ Sci B       Date:  2006-05       Impact factor: 3.066

3.  Delayed cardioprotection is associated with the sub-cellular relocalisation of ventricular protein kinase C epsilon, but not p42/44MAPK.

Authors:  S Wilson; W Song; K Karoly; T Ravingerova; A Vegh; J Papp; S Tomisawa; J R Parratt; N J Pyne
Journal:  Mol Cell Biochem       Date:  1996 Jul-Aug       Impact factor: 3.396

Review 4.  Delayed myocardial protection following ischaemic preconditioning.

Authors:  G F Baxter; D M Yellon
Journal:  Basic Res Cardiol       Date:  1996 Jan-Feb       Impact factor: 17.165

5.  Differential role of PI3K/Akt pathway in the infarct size limitation and antiarrhythmic protection in the rat heart.

Authors:  Tána Ravingerová; Jana Matejíková; Jan Neckár; Eva Andelová; Frantisek Kolár
Journal:  Mol Cell Biochem       Date:  2006-10-03       Impact factor: 3.396

6.  Direct evidence that protein kinase C plays an essential role in the development of late preconditioning against myocardial stunning in conscious rabbits and that epsilon is the isoform involved.

Authors:  Y Qiu; P Ping; X L Tang; S Manchikalapudi; A Rizvi; J Zhang; H Takano; W J Wu; S Teschner; R Bolli
Journal:  J Clin Invest       Date:  1998-05-15       Impact factor: 14.808

7.  Role of protein kinase C and 72 kDa heat shock protein in ischemic tolerance following heat stress in the rat heart.

Authors:  R C Kukreja; Y Z Qian; S Okubo; E E Flaherty
Journal:  Mol Cell Biochem       Date:  1999-05       Impact factor: 3.396

8.  Pharmacological evidence that inducible nitric oxide synthase is a mediator of delayed preconditioning.

Authors:  J Imagawa; D M Yellon; G F Baxter
Journal:  Br J Pharmacol       Date:  1999-02       Impact factor: 8.739

9.  Reactive oxygen species in early and delayed cardiac adaptation.

Authors:  E Roth; M T Jaberansari
Journal:  Exp Clin Cardiol       Date:  2001

10.  Protein kinase C-dependent activation of P44/42 mitogen-activated protein kinase and heat shock protein 70 in signal transduction during hepatocyte ischemic preconditioning.

Authors:  Yi Gao; Yu-Qiang Shan; Ming-Xin Pan; Yu Wang; Li-Jun Tang; Hao Li; Zhi Zhang
Journal:  World J Gastroenterol       Date:  2004-04-01       Impact factor: 5.742
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