Literature DB >> 7544492

Functional characterization and developmental regulation of mouse telomerase RNA.

M A Blasco1, W Funk, B Villeponteau, C W Greider.   

Abstract

Telomerase synthesizes telomeric DNA repeats onto chromosome ends de novo. The mouse telomerase RNA component was cloned and contained only 65 percent sequence identity with the human telomerase RNA. Alteration of the template region in vivo generated altered telomerase products. The shorter template regions of the mouse and other rodent telomerase RNAs could account for the shorter distribution of products (processivity) generated by the mouse enzyme relative to the human telomerase. Amounts of telomerase RNA increased in immortal cells derived from primary mouse fibroblasts. RNA was detected in all newborn mouse tissues tested but was decreased during postnatal development.

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Year:  1995        PMID： 7544492     DOI： 10.1126/science.7544492

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  113 in total

1.  Two inactive fragments of the integral RNA cooperate to assemble active telomerase with the human protein catalytic subunit (hTERT) in vitro.

Authors:  V M Tesmer; L P Ford; S E Holt; B C Frank; X Yi; D L Aisner; M Ouellette; J W Shay; W E Wright
Journal:  Mol Cell Biol       Date:  1999-09       Impact factor: 4.272

2.  Establishment of novel human esophageal cancer cell line in relation to telomere dynamics and telomerase activity.

Authors:  Y Kiyozuka; A Asai; D Yamamoto; H Senzaki; S Yoshioka; H Takahashi; K Hioki; A Tsubura
Journal:  Dig Dis Sci       Date:  2000-05       Impact factor: 3.199

3.  Interference footprinting analysis of telomerase elongation complexes.

Authors:  S Benjamin; N Baran; H Manor
Journal:  Mol Cell Biol       Date:  2000-06       Impact factor: 4.272

4.  The catalytic subunit of telomerase is expressed in developing brain neurons and serves a cell survival-promoting function.

Authors:  W Fu; M Killen; C Culmsee; S Dhar; T K Pandita; M P Mattson
Journal:  J Mol Neurosci       Date:  2000 Feb-Apr       Impact factor: 3.444

5.  Telomere maintenance in telomerase-deficient mouse embryonic stem cells: characterization of an amplified telomeric DNA.

Authors:  H Niida; Y Shinkai; M P Hande; T Matsumoto; S Takehara; M Tachibana; M Oshimura; P M Lansdorp; Y Furuichi
Journal:  Mol Cell Biol       Date:  2000-06       Impact factor: 4.272

6.  The promoter of the heterochromatic Drosophila telomeric retrotransposon, HeT-A, is active when moved into euchromatic locations.

Authors:  Janet A George; Mary-Lou Pardue
Journal:  Genetics       Date:  2003-02       Impact factor: 4.562

7.  Telomere length regulation during postnatal development and ageing in Mus spretus.

Authors:  G M Coviello-McLaughlin; K R Prowse
Journal:  Nucleic Acids Res       Date:  1997-08-01       Impact factor: 16.971

8.  Impaired germinal center reaction in mice with short telomeres.

Authors:  E Herrera; C Martínez-A; M A Blasco
Journal:  EMBO J       Date:  2000-02-01       Impact factor: 11.598

9.  E2F-1 represses transcription of the human telomerase reverse transcriptase gene.

Authors:  D L Crowe; D C Nguyen; K J Tsang; S Kyo
Journal:  Nucleic Acids Res       Date:  2001-07-01       Impact factor: 16.971

10.  Telomerase activity and cell apoptosis in colon cancer cell by human telomerase reverse transcriptase gene antisense oligodeoxynucleotide.

Authors:  Ying-An Jiang; He-Sheng Luo; You-Yuan Zhang; Li-Fang Fan; Chong-Qing Jiang; Wei-Jin Chen
Journal:  World J Gastroenterol       Date:  2003-09       Impact factor: 5.742
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