Literature DB >> 7544445

Effect of domoic acid on metabolism of 5-hydroxytryptamine in rat brain.

B Arias1, M Arufe, M Alfonso, R Duran.   

Abstract

Domoic acid (Dom) is a neurotoxic secondary amino acid that interacts with the glutamate receptors, producing neurological problems. In the present work, we study the effects of Dom on the levels of serotonin (5-HT) and 5-hydroxyindoleacetic acid (5-HIAA) in discrete rat brain regions. The effects of Dom on the brain metabolism of serotonin are also discussed in this paper. Dom stimulates the rat brain serotoninergic system, increasing differentially the synthesis and the catabolism of 5-HT and the elimination of 5-HIAA.

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Year:  1995        PMID： 7544445     DOI： 10.1007/bf00973094

Source DB:  PubMed          Journal:  Neurochem Res        ISSN： 0364-3190            Impact factor:   3.996


  10 in total

1.  Domoic and quisqualic acids as potent amino acid excitants of frog and rat spinal neurones.

Authors:  T J Biscoe; R H Evans; P M Headley; M Martin; J C Watkins
Journal:  Nature       Date:  1975-05-08       Impact factor: 49.962

2.  Neurological sequelae of domoic acid intoxication.

Authors:  J Teitelbaum; R J Zatorre; S Carpenter; D Gendron; N R Cashman
Journal:  Can Dis Wkly Rep       Date:  1990-09

3.  Amnesic shellfish poisoning: a new clinical syndrome due to domoic acid.

Authors:  T M Perl; L Bédard; T Kosatsky; J C Hockin; E C Todd; L A McNutt; R S Remis
Journal:  Can Dis Wkly Rep       Date:  1990-09

4.  The toxicology of domoic acid administered systemically to rodents and primates.

Authors:  F Iverson; J Truelove; L Tryphonas; E A Nera
Journal:  Can Dis Wkly Rep       Date:  1990-09

5.  Does brain 5-HIAA indicate serotonin release or monoamine oxidase activity?

Authors:  W A Wolf; M B Youdim; D M Kuhn
Journal:  Eur J Pharmacol       Date:  1985-03-12       Impact factor: 4.432

6.  A semiautomated analysis method for catecholamines, indoleamines, and some prominent metabolites in microdissected regions of the nervous system: an isocratic HPLC technique employing coulometric detection and minimal sample preparation.

Authors:  I C Kilpatrick; M W Jones; O T Phillipson
Journal:  J Neurochem       Date:  1986-06       Impact factor: 5.372

7.  In vivo measurement of brain serotonin turnover.

Authors:  N H Neff; T N Tozer
Journal:  Adv Pharmacol       Date:  1968

8.  Regulation of 5-hydroxytryptamine synthesis.

Authors:  D A Bender
Journal:  Proc Nutr Soc       Date:  1978-09       Impact factor: 6.297

9.  Domoic acid, the alleged "mussel toxin," might produce its neurotoxic effect through kainate receptor activation: an electrophysiological study in the dorsal hippocampus.

Authors:  G Debonnel; L Beauchesne; C de Montigny
Journal:  Can J Physiol Pharmacol       Date:  1989-01       Impact factor: 2.273

10.  Reduced neuroexcitatory effect of domoic acid following mossy fiber denervation of the rat dorsal hippocampus: further evidence that toxicity of domoic acid involves kainate receptor activation.

Authors:  G Debonnel; M Weiss; C de Montigny
Journal:  Can J Physiol Pharmacol       Date:  1989-08       Impact factor: 2.273
  10 in total
  2 in total

1.  In vivo release of dopamine and its metabolites from rat striatum in response to domoic acid.

Authors:  B Arias; R Durán; M Alfonso
Journal:  Neurochem Res       Date:  1998-12       Impact factor: 3.996

Review 2.  Domoic acid-induced neurotoxicity in the hippocampus of adult rats.

Authors:  Ananth Chandrasekaran; Gopalakrishnakone Ponnambalam; Charanjit Kaur
Journal:  Neurotox Res       Date:  2004       Impact factor: 3.911
  2 in total

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