Literature DB >> 7544223

Inhibition of nitric oxide synthase dramatically potentiates seizures induced by kainic acid and pilocarpine in rats.

R Maggio1, F Fumagalli, E Donati, P Barbier, G Racagni, G U Corsini, M Riva.   

Abstract

We investigated whether the severity of convulsions evoked by kainic acid and pilocarpine is modified in nitric oxide synthase inhibitor-treated rats. We found that chronic treatment (4 days) with NW-nitro-L-arginine greatly potentiates seizures induced by both convulsants suggesting a potential role for nitric oxide in mechanisms regulating seizure induction and propagation.

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Year:  1995        PMID： 7544223     DOI： 10.1016/0006-8993(95)00217-e

Source DB:  PubMed          Journal:  Brain Res        ISSN： 0006-8993            Impact factor:   3.252


  7 in total

1.  NG-nitro-L-arginine, a nitric oxide synthase inhibitor, and seizure susceptibility in four seizure models in mice.

Authors:  E M Urbańska; E Drelewska; K K Borowicz; P Błaszczak; Z Kleinrok; S J Czuczwar
Journal:  J Neural Transm (Vienna)       Date:  1996       Impact factor: 3.575

2.  Anticonvulsant effects of 7-nitroindazole in rodents with reflex epilepsy may result from L-arginine accumulation or a reduction in nitric oxide or L-citrulline formation.

Authors:  S E Smith; C M Man; P K Yip; E Tang; A G Chapman; B S Meldrum
Journal:  Br J Pharmacol       Date:  1996-09       Impact factor: 8.739

3.  The interactions of nitric oxide and acetylcholine on penicillin-induced epilepsy in rats.

Authors:  Abdullah Hilmi Marangoz; Mehmet Yildirim; Mustafa Ayyildiz; Cafer Marangoz
Journal:  Neurochem Res       Date:  2012-03-08       Impact factor: 3.996

4.  Nitric oxide content measured by ESR-spectroscopy in the rat brain is increased during pentylenetetrazole-induced seizures.

Authors:  V Bashkatova; G Vitskova; V Narkevich; A Vanin; V Mikoyan; K Rayevsky
Journal:  J Mol Neurosci       Date:  2000-06       Impact factor: 3.444

5.  The anticonvulant effect of cooling in comparison to α-lipoic acid: a neurochemical study.

Authors:  Yasser A Khadrawy; Heba S Aboulezz; Nawal A Ahmed; Haitham S Mohammed
Journal:  Neurochem Res       Date:  2013-02-07       Impact factor: 3.996

6.  Temporal and spatial increase of reactive nitrogen species in the kainate model of temporal lobe epilepsy.

Authors:  Kristen Ryan; Li-Ping Liang; Christopher Rivard; Manisha Patel
Journal:  Neurobiol Dis       Date:  2013-12-19       Impact factor: 5.996

7.  Effect of Lenalidomide on Pentylenetetrazole-Induced Clonic Seizure Threshold in Mice: A Role for N-Methyl-D-Aspartic Acid Receptor/Nitric Oxide Pathway.

Authors:  Elaheh Asgari Dafe; Nastaran Rahimi; Nina Javadian; Pegah Dejban; Monika Komeili; Sepideh Modabberi; Mehdi Ghasemi; Ahmad Reza Dehpour
Journal:  J Epilepsy Res       Date:  2021-06-30
  7 in total

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