Literature DB >> 7544046

Analysis of human immunodeficiency virus type 1 integrase mutants.

M A Ansari-Lari1, L A Donehower, R A Gibbs.   

Abstract

The human immunodeficiency virus type-1 (HIV-1) integrase protein (IN) mediates the insertion of linear double-stranded viral DNA into the host genome. Mutations in IN can have different effects on the virus life cycle. In this study, Gag-Pol polyprotein processing, Tat synthesis, and viral replication were investigated in integrase-defective HIV-1 mutants. In the absence of IN synthesis, the Gag-Pol polyprotein stability, packaging, and/or processing was reduced. There was limited expression of Tat observed in IN mutants, but no viral replication.

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Year:  1995        PMID： 7544046     DOI： 10.1006/viro.1995.1412

Source DB:  PubMed          Journal:  Virology        ISSN： 0042-6822            Impact factor:   3.616


  39 in total

1.  Correlation of recombinant integrase activity and functional preintegration complex formation during acute infection by replication-defective integrase mutant human immunodeficiency virus.

Authors:  Xiang Li; Yasuhiro Koh; Alan Engelman
Journal:  J Virol       Date:  2012-01-25       Impact factor: 5.103

2.  Incorporation of functional human immunodeficiency virus type 1 integrase into virions independent of the Gag-Pol precursor protein.

Authors:  H Liu; X Wu; H Xiao; J A Conway; J C Kappes
Journal:  J Virol       Date:  1997-10       Impact factor: 5.103

3.  Preliminary mapping of a putative inhibitor-binding pocket for human immunodeficiency virus type 1 integrase inhibitors.

Authors:  Deborah J Lee; W Edward Robinson
Journal:  Antimicrob Agents Chemother       Date:  2006-01       Impact factor: 5.191

4.  Patients on HAART often have an excess of unintegrated HIV DNA: implications for monitoring reservoirs.

Authors:  Luis M Agosto; Megan K Liszewski; Angela Mexas; Erin Graf; Matthew Pace; Jianqing J Yu; Avinash Bhandoola; Una O'Doherty
Journal:  Virology       Date:  2011-01-05       Impact factor: 3.616

5.  Lack of integrase can markedly affect human immunodeficiency virus type 1 particle production in the presence of an active viral protease.

Authors:  A Bukovsky; H Göttlinger
Journal:  J Virol       Date:  1996-10       Impact factor: 5.103

6.  Reversion of a human immunodeficiency virus type 1 integrase mutant at a second site restores enzyme function and virus infectivity.

Authors:  B Taddeo; F Carlini; P Verani; A Engelman
Journal:  J Virol       Date:  1996-12       Impact factor: 5.103

7.  Inhibition of early and late events of the HIV-1 replication cycle by cytoplasmic Fab intrabodies against the matrix protein, p17.

Authors:  R Levin; A M Mhashilkar; T Dorfman; A Bukovsky; C Zani; J Bagley; J Hinkula; M Niedrig; J Albert; B Wahren; H G Göttlinger; W A Marasco
Journal:  Mol Med       Date:  1997-02       Impact factor: 6.354

8.  Early transcription from nonintegrated DNA in human immunodeficiency virus infection.

Authors:  Yuntao Wu; Jon W Marsh
Journal:  J Virol       Date:  2003-10       Impact factor: 5.103

9.  Replication of chimeric human immunodeficiency virus type 1 (HIV-1) containing HIV-2 integrase (IN): naturally selected mutations in IN augment DNA synthesis.

Authors:  Marcus Padow; Lilin Lai; Champion Deivanayagam; Lawrence J DeLucas; Robert B Weiss; Diane M Dunn; Xiaoyun Wu; John C Kappes
Journal:  J Virol       Date:  2003-10       Impact factor: 5.103

10.  Expression of human immunodeficiency virus type 1 reverse transcriptase in trans during virion release and after infection.

Authors:  M A Ansari-Lari; R A Gibbs
Journal:  J Virol       Date:  1996-06       Impact factor: 5.103
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